autoimmunity

  1. Pyrrhus

    Autoimmunity Research in ME/CFS

    Autoimmunity Research in ME/CFS I thought I would start a thread summarizing the research publications related to auto-immunity in ME. Please feel free to add new publications as appropriate. I'll start with Carmen Scheibenbogen's work. Here is the 2015 paper by Carmen Scheibenbogen that...
  2. Pyrrhus

    The Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoimmunity (Lodha et al., 2022)

    The Hidden Enemy Within: Non-canonical Peptides in Virus-Induced Autoimmunity (Lodha et al., 2022) https://doi.org/10.3389/fmicb.2022.840911 An article from Bhupesh Prusty about cryptic antigens, which are one way that viruses can cause auto-immunity. To learn more about cryptic antigens...
  3. Pyrrhus

    How Viruses Cause Autoimmunity

    :monocle: I thought I would start a thread to summarize discussions about the research on how viruses can cause autoimmunity. :monocle: We already have two good discussions about papers which describe the ways in which viral infections, or chronic inflammation, can cause autoimmunity: How...
  4. Gingergrrl

    How pandemics strengthen links between viruses and autoimmunity (journal article from "Nature")

    This is a really interesting article from the Journal "Nature" called, "How pandemics strengthen links between viruses and autoimmunity". Here is the link: https://www.nature.com/articles/d41586-021-01835-w The article is a little bit long but was super interesting (at least to me :nerd:)...
  5. C

    Hypothalamic-Pituitary autoimmunity and related impairment of hormone secretions in chronic fatigue syndrome

    https://pubmed.ncbi.nlm.nih.gov/34254637/ Hypothalamic-Pituitary autoimmunity and related impairment of hormone secretions in chronic fatigue syndrome Annamaria De Bellis, 1, 2, Giuseppe Bellastella, 2, 3, Vlenia Pernice, 2, Paolo Cirillo, 2, Miriam Longo, 2, 3...
  6. sometexan84

    You probably have an autoimmune disease...

    31 of 364 ME/CFS patients tested positive for at least 1 of 4 autoantibodies in this study for small-fiber polyneuropathy. Those 31 patients have pretty much identified the cause of their fatigue. So you think, "well that's less than 10%, so I'm not likely part of that group". Wrong. You...
  7. R

    Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Efficacy of Repeat Immunoadsorption - Published: 30 July 2020

    https://www.mdpi.com/2077-0383/9/8/2443/htm Abstract (1) Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex neuroimmunological disease. There is evidence for an autoimmune mechanism for ME/CFS with an infection-triggered onset and dysfunction of ß2-adrenoreceptor...
  8. Annikki

    Study about infection-triggered autoimmune disease, Multiple Sclerosis, EBV and Theiler’s murine encephalomyelitis virus

    Sorry for the cumbersome title, but the following study is definitely worth looking at. I love it because it reflects my idea that an external trigger, i.e. an entity with different DNA (or RNA) from your own triggers ME. Many of us got ME after having a "run of the mill" viral infection. I...
  9. pattismith

    IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS

    Brain, Behavior, & Immunity - Health Available online 5 February 2020, 100047 IgG stimulated β2 adrenergic receptor activation is attenuated in patients with ME/CFS Author links open overlay...
  10. Murph

    Searching for Serum Antibodies to Neuronal Proteins in Patients With ME/CFS (Giannocaro, Fluge et al 2019)

    Clin Ther. 2019 Apr 30. pii: S0149-2918(19)30163-8. doi: 10.1016/j.clinthera.2019.04.001. [Epub ahead of print] Searching for Serum Antibodies to Neuronal Proteins in Patients With Myalgic Encephalopathy/Chronic Fatigue Syndrome. Giannoccaro MP1, Cossins J2, Sørland K3, Fluge Ø3, Vincent A2...
  11. T

    Is Auto immunity possible without positive ANA and elevated CRP

    Is it possible to have auto immunity issues with negative ANA and not that high CRP?
  12. Malea

    Autoantibodies and ANAs

    I have to tell my (family) doctor tommorrow about the autoantibodies I tested positive for. (Adrenergic, muscarinic ACh and angiotensin) At the same time I have negative ANAs (1:80) and I worry that my doctor will think that there can‘t be a problem because of the negative ANAs. (That is what a...
  13. Murph

    Immunoadsorption to remove ß2 adrenergic receptor antibodies in CFS/ME.

    PLoS One. 2018 Mar 15;13(3):e0193672. doi: 10.1371/journal.pone.0193672. eCollection 2018. Immunoadsorption to remove ß2 adrenergic receptor antibodies in Chronic Fatigue Syndrome CFS/ME. Scheibenbogen C1,2, Loebel M1, Freitag H1, Krueger A3, Bauer S1, Antelmann M1, Doehner W4, Scherbakov N4...
  14. Jesse2233

    List of ME/CFS + POTS Related Autoantibody Panels (That Your Doctor Can Run)

    Posting this in the hopes that it helps someone better determine an autoimmune etiology and move down an appropriate path of treatment (e.g. anti-inflammatories / immunomodulators / immunosuppressants). At very least these labs may point to a verifiable disease process when other labs are...
  15. D

    "Antibodies to adrenergic and muscarinic receptors in ME/CFS" (August 29 blog post)

    Antibodies to adrenergic and muscarinic receptors in ME/CFS Paolo Maccalliniin agosto 29, 2017 1,396 Words https://paolomaccallini.wordpress.com/2017/08/29/antibodies-to-adrenergic-and-muscarinic-receptors-in-mecfs/
  16. mango

    Antiadrenergic autoimmunity in postural tachycardia syndrome (Fedorowski et al., 2016)

    Antiadrenergic autoimmunity in postural tachycardia syndrome Artur Fedorowski1,2,*,†, Hongliang Li3, Xichun Yu3, Kristi A. Koelsch3,4, Valerie M. Harris3,4, Campbell Liles3, Taylor A. Murphy3, Syed M.S. Quadri3,4, Robert Hal Scofield3,4, Richard Sutton5, Olle Melander1 and David C. Kem3,† 1...
  17. snowathlete

    Antibodies to ß adrenergic and muscarinic cholinergic receptors in patients with CFS

    Loebel, Grabowski, Heidecke, Bauer, Hanitsch, Wittke, Meisel, Reinke, Volk, Fluge Ø, Mella, Scheibenbogen. Abstract Infection-triggered disease onset, chronic immune activation and autonomic dysregulation in CFS point to an autoimmune disease directed against neurotransmitter receptors...
  18. heapsreal

    The role of infections in autoimmune disease

    ABSTRACT Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the development of autoimmune diseases. In this...