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List of ME/CFS + POTS Related Autoantibody Panels (That Your Doctor Can Run)


Senior Member
Southern California
Posting this in the hopes that it helps someone better determine an autoimmune etiology and move down an appropriate path of treatment (e.g. anti-inflammatories / immunomodulators / immunosuppressants).

At very least these labs may point to a verifiable disease process when other labs are normal.

Caveat: these autoantibodies can show up in healthy people, and any treatment based on them should be assessed in conjunction with one's clinical picture, other labs, and a healthcare professional.

I am in contact with a researcher / immunologist in Sweden who is working on a new rhodopsin antibody assay for POTS. It is not yet available for public use, but I will update when it is.


The way I get doctors (in the US) to test for these is:

  1. Print out the lab order w/ appropriate test codes

  2. Take the lab order to a GP and say "I have a post-infectious autoimmune condition. My specialist would like to test for these antibodies" (all of which are true).

  3. I've not had any issues doing this with two different GPs. However, if this fails, one can consult a Integrative Medicine doctor or a Naturopath.
Note: The Quest and Lab Corp autoantibody tests need to be searched for individually

Cyrex Array 5 - Multiple Autoimmune Reactivity Screen
  • Parietal Cell + ATPase antibodies
  • Intrinsic Factor antibodies
  • ASCA + ANCA antibodies
  • Tropomyosin antibodies
  • Thyroglobulin antibodies
  • Thyroid Peroxidase antibodies
  • 21-Hydroxylase (Adrenal Cortex) antibodies
  • Myocardial Peptide antibodies
  • Alpha-Myosin antibodies
  • Phospholipid antibodies
  • Platelet Glycoprotein antibodies
  • Testis antibodies
  • Fibulin antibodies
  • Collagen Complex antibodies
  • Arthritic Peptide antibodies
  • Osteocyte antibodies
  • Cytochrome P450 (Hepatocyte) antibodies
  • Insulin + Islet Cell antibodies
  • Glutamic Acid Decarboxylase 65 antibodies
  • Myelin Basic Protein antibodies
  • Asialoganglioside antibodies
  • Alpha-Tubulin + Beta-Tubulin antibodies
  • Cerebellar antibodies
  • Synapsin antibodies
CellTrend CFS/POTS Diagnostic
  • Anti a-1-adrenergic antibodies
  • Anti a-2-adrenergic antibodies
  • Anti b-1-adrenergic antibodies
  • Anti b-2-adrenergic antibodies
  • Anti-muscarinic cholinergic receptor 1 antibodies
  • Anti-muscarinic cholinergic receptor 2 antibodies
  • Anti-muscarinic cholinergic receptor 3 antibodies
  • Anti-muscarinic cholinergic receptor 4 antibodies
  • Anti-muscarinic cholinergic receptor 5 antibodies
Cunningham Panel
  • Anti-Dopamine Receptor D1
  • Anti-Dopamine Receptor D2L
  • Anti-Lysoganglioside GM1
  • Anti-Tubulin
  • CaM Kinase II
Lab Corp
  • Anti-Mitochondrial Ab
  • Anti-Smooth Muscle Ab
  • Anti-Cardiolipin Ab
  • Rheumatoid Factor IgM
Quest Diagnostics
  • Beta 2 glycoprotein IgG, IgM, IgA
  • Lupus anticoagulant
  • Anti-phosphatidylserine IgG, IgM, IgA
  • Anti-prothrombin IgG (IgM is not currently available due to reagent shortage)
  • Anti-phosphatidylserine-prothrombin IgG, IgM
  • Anti-Annexin V IgG, IgM
  • Anti-phosphatidylethanolamine IgG, IgM
  • ANA by IFA
  • ENA
  • SS-A
  • SS-B
  • Anti TTG IgA
  • Anti Glaidin
MAYO Autoimmune Dysautonomia
  • Striational (Striated Muscle) Ab, S
  • Anti-Neuronal Nuclear Ab, Type 1
  • N-Type Calcium Channel Ab
  • Ach Receptor (Muscle) Minding Ab
  • AcChR Ganglionic Neuronal Ab, S
  • Neuronal (V-G) K+ Channel Ab, S
  • GAD65 Ab Assay, S
  • P/Q Type Calcium Channel Ab
MAYO Autoimmune Encephalitis
  • NMDA-R, Ab CBA, S
  • Neuronal (V-G) K+ Channel Ab, S
  • LG1- IgG CBA, S
  • CASPR2 - IgG CBA, S
  • GABA 8-R Ab CBA, S
  • AMPA-R Ab, CBA, S
  • ANNA-1, S
  • ANNA-2, S
  • AGNA-1, S
  • PCA-1,S
  • PCA-2, S
  • PCA-Tr, S
  • Amphiphysin Ab, S
  • ACh Receptor (muscle) Bind Ab
  • CRMP 5-IgG, S
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Senior Member
Czech Republic
It would be nice to know approximate price for panels too.
I have done Cunningham and celltrend. I'm positive for anti dopamin 1, anti tubulin and 2 celltrend.
I have wide range of neurological symptoms so autoimmune encephalitis is definitely possible but dr. did only these two. I would like to do other panels before starting rituximab though because it would be helpful to have more evidence to fight medical system.


Senior Member
Southern California
I have seen a lot on cell trend and done those but if the others are there opinions on those to prioritise or have most evidence or promise to link to ME?

Anti-cardiolipin pops up in a lot of patients

MAYO panels are more likely to be taken seriously by neurologists and may lead to insurance coverage w/ certain plans, indications, treatments

Cunningham Panel is more common in post-infectious cases


Senior Member
Czech Republic
Do you know how much is Cunningham panel taken seriously by neurologists by any chance (in europe)?
I'm afraid I would hit the wall again if I demand more neuro autoimmune testing.


Senior Member
Wow, great information! I am just researching which antibodies to test.
Main symptoms are leg weakness (thighs) with frequent cramping, tingling, twitching, numbness, cramping in the calfs, worse when I walk a few steps. The same day my gastroparesis (paralized stomach) started, so I always thought the both conditions were interrelated as both are neurological in nature. Doctors have no interest in finding out the cause, but I think it could be autoimmune related.
There is also an autoimmune panel for gi-conditions from the Mayo-clinic:
But this seems to be nearly identic with the dysautonomia panel.

Any suggestions which antibodies make probably sense to test with the combination from muscle problems and gastroparesis? Have to pay this on my own, as I have the kind of "just accept it and live with it-doctor"

Thank you!


Senior Member
I wonder if Medicaid would cover any of the mayo panels.

I would like to know too. All I can expect is that a Medicaid managed care plan may cover the labcorp and quest ones after a bit of fighting. I can't find anything on how much mayo would charge out of pocket, but the Cunningham panel is over $900.

There's price listings available for the common mayo panels, and they're in the thousands.


Senior Member
York, England
Posting this in the hopes that it helps someone better determine an autoimmune etiology and move down an appropriate path of treatment (e.g. anti-inflammatories / immunomodulators / immunosuppressants).

Did anyone ever get to a stage where a specific medication/treatment could be used against any of the above specific auto antibody?