Autoimmunity Research in ME/CFS
I thought I would start a thread summarizing the research publications related to auto-immunity in ME. Please feel free to add new publications as appropriate.
I'll start with Carmen Scheibenbogen's work. Here is the 2015 paper by Carmen Scheibenbogen that found elevated levels of autonomic auto-antibodies in ME:
Antibodies to β adrenergic and muscarinic cholinergic receptors in patients with Chronic Fatigue Syndrome (2015)
This paper reported that, in 29.5% of patients with ME, they found significantly elevated levels of autoantibodies that target three types of neurotransmitter receptors on autonomic nerves, compared to the levels of autoantibodies found in controls. The paper suggested that when these antibodies were depleted by Rituximab treatment, patients experienced an improvement in symptoms.
And here is an updated paper by Carmen Scheibenbogen that used the CellTrend test:
Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (2021)
This paper looked for correlations between certain antibodies and symptoms in ME. They found that levels of these certain antibodies significantly correlated with key symptoms of fatigue and muscle pain in patients with infection-triggered onset, but not in patients without an infection-triggered onset. They further suggest that specific antibodies might show some correlation with specific symptoms.