Food doesn't affect me at all that way.
As a technical point, I'll note that viruses and parasites seem to trigger CFS/ME/SEID/... as well as bacteria.
I would expect that pretty much anything which generates an antibody response has the potential in some cases to create antibodies with accidental autoimmunity.
Antibodies to adrenergic and muscarinic receptors in ME/CFS
Paolo Maccalliniin agosto 29, 2017
@gingergirl. did you do one of the mayo panels or some other testing place? Do you have a thread where you say more about your autoimmune pots?
This paper talks about heart auto-immunity and Sudden Cardiac Death:
"Anti-beta adrenergic receptor antibodies and anti-muscarinic acetylcholine receptor antibodies affect myocardial electrophysiological properties and were reported to be the independent predictors of SCD in patients with different heart diseases. Autoimmune mechanism is proposed for cardiac-related adverse reactions following human papillomavirus (HPV) vaccination. The pentapeptid sharing between HPV's antigens, adrenergic receptors and muscarinic acetylcholine receptors supports this assumption. "
They propose that sudden cardiac death event after HPV vaccine may be related to autoimmunity against β2-adrenergic and M2 muscarinic receptors that are present in the heart.@pattismith Does this article mean that just having the "Anti-beta adrenergic receptor antibodies and anti-muscarinic acetylcholine receptor antibodies" (which I have) increases your risk of sudden cardiac death or does it mean only in people who have also gotten the HPV vaccine (which I have never had). I just wanted to clarify before I panic LOL
They propose that sudden cardiac death event after HPV vaccine may be related to autoimmunity against β2-adrenergic and M2 muscarinic receptors that are present in the heart.
@pattismith You are a treasure to this forum. Keeping it alive and beating me to research all the time. ✊🏿
M1 and M3 are activated for REM sleep, see my thread about it here, where I found a way to have some dreams back (actually more nightmares, so not a perfect result so far).@pattismith That’s really interesting. I actually stumbled onto the m3/REM sleep connection myself and so I’ve been taking Mestinon, magnesium glycinate and some Alpha GPC and BCAAs (mainly isoleucine) to try and increase REM sleep. Still can’t remember my dreams but I smoke a lot of cannabis which kills my ability to remember dreams and takes at least a week break to being back able to. They are always extremely unpleasant when I do have them some I don’t really mind but I do want my precious REM. @pattismith You are a treasure to this forum. Keeping it alive and beating me to research all the time. ✊🏿
Interesting my alpha adrenergic autoantibody were positive not beta although I did test positive for m2. Interesting that it’s only m2 they think involved. Of course from memory I know that m2 and alpha adrenergic are connected. This sounds like the immune system trying to compensate for some extreme stress on the autonomic systems.
We tested the serum of ten narcolepsy type 1 patients (five female) for activating β2 adrenergic receptor autoantibodies, M2 muscarinic receptor autoantibodies, and nociception receptor autoantibodies.
Ten of ten patients were positive for muscarinic M2 receptor autoantibodies (P < 0.001),
9/10 were positive for autoantibodies against nociception receptors (P < 0.001),
and 5/10 were positive for β2 adrenergic receptor autoantibodies (P < 0.001).
Narcolepsy type 1 patients harbored activating autoantibodies against M2 muscarinic receptors, nociception receptors, and β2 adrenergic receptors.
M2 receptor autoantibodies may be related to the occurrence of cataplexy and, moreover, hallucinations in narcolepsy since they are found in the same brain areas that are involved with these symptoms.
The occurrence of nociception receptor autoantibodies strengthens the association between narcolepsy type 1 and pain.
The connection between narcolepsy type 1, autonomic complaints, and the presumed cardiovascular morbidity might be associated with the occurrence of β2 adrenergic receptor autoantibodies.
On the other hand, the presence of the autoantibodies may be secondary to the destruction of the hypocretin pathways.
For me it shows what I've already thought: that these AAB can't be specific (in terms of exclusively positive) for ME. Otherwise more than 30% would have been tested positive.this a new research article on Narcolepsy, it's interesting as narcolepsy goes with short REM latency and vivid dreams.
Activating autoantibodies against G protein-coupled receptors in narcolepsy type 1 - ScienceDirect 2021