Biarritz13
Senior Member
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- 699
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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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I would be careful extrapolating too much from the data that you gather here. There are many people who benefit from augmenting the pathway who do not have CFS and therefore are not here.
As well, people with COMT really need to approach things conservatively.
So you don't add anything up according to symptoms. You start low and build the doses like I did. Start with the mB12 for a week maybe and then work in the folate. Let things settle. You might not feel so hot for a few days. Then when the boat stops rocking for a while add the adeno and so on.
] Many of us needed to have niacin on hand in the early days until we sorted things out. It will deal with extra methyl groups. I had a need of this from time to time until I went from one needle a day to two.
@Theodore forgive my memory lapses, have you tried FMN? Seems especially good for MAO snps. See my experience in my signature. (unless you and I have already had this conversation)
I've read about using niacin to determine whether your over/under methylated. Historically the same niacin dose always produced a big flush. Now, even with doubling, the dose only causes a slight flush. The flush I had seemed to cause my mind to calm some and that doesn't seem to be happening anymore. I've cut back my methylfolate, but it still seems like no flush/calm. I'm not sure what to make of this. Should I cut back further? Try reducing TMG/LCF?
Niacin will not cause the same degree of flushing after a while. This seems to be a universal adaptation. Whether as a response to the flush or some other mechanism, niacin seems to release endorphins. This makes people relaxed and lots start to look forward to the next dose. I don't think that there is any reason to intervene.
The itching/calm held steady for months. Then I started probiotics. In the course of the next week the flush completely went away. I took this to indicate I was much more methylated due to better bacteria and lowered my dosages.
Do you think I misinterpreted the degree of methylation?
The other thing was that the Dr put me on high dose niacin which was a treatment for high cholesterol.
Two years later, I had my first hospitalization for Bipolar Disorder.