weird OI: standing up stops my digestion
...Wether carcinine has in some ways similar effects to ALA or not would then be a next step...
When searching how ALA increases energy production and if there aren't any downsides, I stumbled over this little stray comment:
udah3 months ago
"ALA drains your B vitamins in high enough doses according to Dr Burt Berkson who is one of the first people to use it to reverse liver failure among other things. So prob should supplement with a good B complex"
- Now, there are 10⁹ such comments on everything on the net. This one I find interesting because this Burt Berkson is a big proponent of ALA, and if even he says it drains B's then it probably does. Unfortunately, I did not find the original source and, for an unknown reason, the youtube comment author did not include his list of references
Here things get more concrete:
Taking alpha-lipoic acid in the presence of a Thiamine (vitamin B1) deficiency can cause serious health issues
- I guess these "serious issues" may be in the range of beriberi to Wernicke's encephalopathy: B1 deficit illnesses.
And this research hypothesis is the most interesting thing I found:
Korotchkina et al reported that ALA inhibits pyruvate dehydrogenase kinase.19 This is the enzyme that disables the pyruvate dehydrogenase complex. Consequently, ALA speeds up the conversion of pyruvate to acetyl Co A.
It is our hypothesis that ALA is the rate-limiting agent in the production of energy from carbohydrate and protein in aerobic eukaryotes. With appropriate ALA levels, the mitochondrion functions normally. If the mitochondrion does not obtain sufficient ALA, it suffers and the organism lacks energy.
Conversely, if the mitochondrion is supplied with excessive amounts of ALA, it accelerates aerobic respiration and the process runs ahead of the other necessary constituents. The mitochondrion then heats up, and its membranous components break down. Severe damage to the mitochondrion is first seen by gross swelling and then severe damage to the cristae and matrix material.
Now, putting it all together, and rephrasing it in plain English:
- The cell usually produces far less energy than it could (otherwise ALA would not work to increase energy production)
- When more ALA is put in, it turns the big lever mentioned above ("pyruvate dehydrogenase kinase") and thus all the energy-production machinery of the cell starts working full capacity, evidently using up everything that is usually needed for energy production. So in this sense, I feel it is a good way to describe it as "ALA is activating usage of B" as @Gondwanaland put it.
- For anyone not familiar with details of energy production: it is not only vitamin C and B1 that are needed for energy production, but all the Bs.
- While ALA is sometimes pictured as "antioxidant to protect x, y and z", it seems equally that the to the contrary, low natural amounts of ALA in cells protect from damage incurred by energy production. Kinda "better not constantly drive your car at 200km/h".
- Conclusion: ALA may help to produce more energy. And there can be important reasons to need more energy, because that energy may rescue you from a leopard / infection / illness x y...But then better fuel up with all those vitamins that are needed along all energy production pathways, most notably, the B's, to minimize damage.
Just for fun: do you know Wim Hof? He can immerse for 2 hours into ice cubes. What happens with his mitos during this time? I hope he has enough B's...