YippeeKi YOW !!

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@Howard
Idiopathic Gastroparesis [C]

This is a fun one. So, in the very severe cases, the virus can infect your vagus nerve causing GP. And most "idiopathic" cases are really just EV. 9 out of 10 of idiopathic cases turned up to be EV and it seems a minor subset is also caused by your lovely neighborhood friend, Norovirus. The underlying mechanism is again, infection, likely through the CNS and/or ENS. Also, keep in mind these viruses love to travel up through the vagus nerve and use it like a highway to evade your immune system and reach places like your brain and eyes.

https://link.springer.com/article/10.1007/s10620-016-4227-x

https://pubmed.ncbi.nlm.nih.gov/27344315/

https://www.cureus.com/articles/21623-norovirus-induced-gastroparesis

Idiopathic Mast Cell Disease/Activation Syndrome [B]

This is only a small part of @Thebirdman333 's gobsmackingly encyclopedic post. I got as far as this, and then my brain, which had already been screaming for a truce, started really hurting. I'm coming back to finish it, probably tomorrow, but I thought that this part might be of particular interest to you ...


@Thebirdman333
WOW. Words fail me, which is unusual. How you pulled all this remarkable compendium together is just .... damn .... words fail me, again. Even with some of the necessary bridging speculation, there's clues and breadcrumb trails and hints that chip away at a lot of the currently received wisdom, at least as well as I understood most of it. Or some of it. At least I think I did.


Thank you for the enormous effort and the massive amount of research that went into this, it's truly spectacular !!!! :jaw-drop::jaw-drop: :woot::woot::woot::woot: :thumbsup::thumbsup:
 

YippeeKi YOW !!

Senior Member
Messages
16,075
Location
Second star to the right ...
And, of course, there's also the historical bias:
I wish I could like this multiple times. That historical bias has long tentacles and a far reach, and it infects everything it touches.

We've lost so much knowledge and brilliance in the field and to watch them find out things all over again from scratch is really depressing.
History repeating itself, or at least rhyming. We build civilizations, burn them to the ground and dismantle what's left stone by stone, then build them again with no memory of what's already gone before.

It's majorly depressing.
 
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