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Thanks so much for your input. I will definitely take the Yasko recs with a grain of salt. The only reason I think it might be something good to try, is because of previous bad experience with MB injections and some of the symptoms I've had with FP, which may not have anything to do with MB sublinguals I'm taking. As mentioned before it could be from major hormone fluctuations too. I just remember feeling great when I used to take Hydroxy injections years ago. Also I still have a lot of problems with taking Adeno after trying to titrate for months, and with Hydroxy injections I might not have to take extra Adeno since Hydroxy breaks down into MB + Adeno.@surfbaby, I don't use hydroxy, I inject methyl. My advice is not go too much on snps when choosing your supps, but rather try stuff and see what works for you.
Yasko's recs based on DNA don't have a very good rep with a lot of smart people around here whose brains I really respect. She seems to churn out a lot of recs based on not much evidence, either scientific or heavily documented anecdotal.
FWIW, my take on scientists and healers who gain some celebrity with really good, sound, cutting edge advice and theories early on often resort to churning out questionable advice and theories later on, possibly just to try and stay on the cutting edge and maintain "preeminence" and celebrity in their field. That may or may not be the case with Yasko, but it's a definite phenomenon and therefore worth considering in her case. The urge to stay ahead of the pack can be very potent in any career.
At any rate, since she can't have any idea all snps a person has, or how those snps are going to interact with one another, it's probably not good to base a protocol based on DNA recs without trying all avenues. Try cautiously, if you're leery of bad effect, but by all means try everything before you make a decision.
I love injectable mB12 and plan never to be without for the rest of my life. Worth noting is I have multiple MTRR mutations which are supposed to affect my B12. But I found this out after I already fell in love with the injectable mB12. Analysis of my DNA has served mostly as confirmation about things I've already observed about my body.
I think snps are probably most useful as a guide of where to start your course of healing, and to keep you pointed in the right directions, but not necessarily as a guide to what forms of the supplements you choose to take. For example, I tried injectable mB12 simply because I wasn't getting the results I wanted from sublingual mB12, and the methyl form is supposed to pack the biggest punch. If I didn't like methyl I would have then tried hydroxy. I never had to try hydroxy because methyl is exactly what I need, but that's how it would have gone if mB12 hadn't worked for me. That's basically how I've chosen every form of supplement I use. I don't worry about what the literature says, it's all about what my body says. And we don't really know what our body says about a thing until we try the thing out.
So if you want to try hydroxy, do it. But if it doesn't give you the results you want or think you should have, try methyl. Don't get too hung up on your snps at any point.
Just my $0.02. Good luck!
Edited to add: the dosing schedule depends upon the person. I used to do best taking a big injection in the morning and sometimes a small one later in the day, and then dividing my folate dose into small multiple doses throughout the day. Now I just take a small injection and a small amount of folate in the morning. That lasts me all day.
When I needed big injections I went with the 12.5mg/ml formulation of mB12. I would inject about half a mg of that. Now I get the 1mg/ml formulation and do about 1/3 - 1/2 mg per day of that. Formulation doesn't really matter as far as how much b12 you can take...it's possible although not desirable to inject 12 full mg of B12 from a 1mg/ml formulation. But that would take a loooong time to draw and it would sting going in. You'd have to divide it up into multiple injections.
But if you get the 12.5mg/ml formulation if you need a larger dose, you can draw a much smaller amount into a small insulin syringe with a very, very thin needle, but still get your bigger dose. These days I can get by with an insulin syringe even with the 1mg/ml formulation, because I don't need more than 1ml per day.
I inject subcutaneously into my abdominal area. Most of the time I don't feel a thing. The needle is very thin and the area is not sensitive. The needle isn't going into your muscle, which is what usually hurts the most when getting a shot. My daily B12 injections are almost like watching someone else get injected. Literally.
I am concerned about switching since Freddd is opposed to anything besides MB, and he also felt that way over 10 years ago when I contacted him on a different forum when I was taking Hydroxy injections for a severe B-12 deficiency that almost crippled me (which was caused by a very high folic acid, not MF, medical protocol that threw my B-12 way out of balance, and is why I think it's important to get the doses right). I had a bad reaction to MB injections at that time which is why I was taking Hydroxy, although years later I did try small doses of MB injections but never could figure out a dose that made me feel better, although I didn't know about MF back then. I'm not opposed to MB injections in the future when my doses are higher, but for now if I'm going to try anything different from the MB sublinguals, I would like to try Hydroxy injections first. (And as mentioned before for some reason MB sublinguals agreed with me better than Hydroxy sublinguals in the past, but it seemed to be the opposite with the injections. Don't know why, but maybe it was because I wasn't taking MF and doing FP like now.)
I have had quite a bit of experience with doing both Hydroxy and MB subcutaneous injections with very small insulin needle (using more concentrated formulation like you) in the past but not with this protocol, so I feel comfortable with doing them, just not thrilled. I know what you mean about the different concentrations, but I just wasn't sure if the formulation mattered, because it seems like a more concentrated solution might take longer to be absorbed, and perhaps that would have to be factored in.
When you started your MB injections, how did you know how to translate the amount you were taking sublingually into injectable? I know it will be trial and error, but it would be good to have some kind of starting point. I was thinking that if someone was going from MB sublingual to MB injectable, they might start with a dose of 20% since I think that's the maximum amount that Freddd says you absorb from a 5 star sublingual like the ET MB sublingual I take. Is that right? It would then be a bit more complicated to then translate that into a Hydroxy injection dosage, because Hydroxy still has to break down into MB + Adeno, so you would probably have to inject more Hydroxy than if you were injecting MB, as you would likely ultimately get less MB from a Hydroxy shot. If I at least had a starting point of the amount someone going from MB sublingual to MB injectable would take, then I could just guess at a slightly higher Hydroxy dose to try. Or I could just start with the standard dose of 1mg, but I would be concerned about the amount of folate I'm taking now being out of balance with such a low dose (too much folate in proportion to the small amount of MB I might get from only 1mg Hydroxy, and remember what happened to me 10 yrs ago). Do you know anyone else in the forum who might be able to help?
I like the idea of one injection per day to start and then spreading out the folate in 3 doses throughout the day of 700-800mcg each like I'm doing now. When you said you started that way with small folate doses, how big were your folate doses and how often? You said you were doing about half a mg of 12.5mg/ml (about 6mg MB injected), so I'm just wondering in proportion how much folate you were taking with that. You must have been at much higher doses than me at that time, because I only take 5.5mg/day ET MB now, but that's sublingual. It seems to make sense to stick with the folate dose I'm doing now, if only I can get the Hydroxy dose right. One injection should do the trick because Hydroxy supposedly stays in the body longer and it takes longer to break down. The pharmacist said that people who take MB daily might only need to do Hydroxy every other day, but she doesn't know anything about FP, so I don't want to go by what she says.
Hope to hear back from you soon as you are giving me the only hope that I might be able to figure this out at this point. I'm not great with change, tho I should be brave and try something different if I'm still not feeling great. But if it seems too risky, I might just stay with the MB sublinguals for awhile. On a completely random note, do you have any idea on how to titrate Sam-e? I used to take that with no problem 5 years ago but cannot tolerate it now. A couple hours after taking it, it makes me feel completely spun out and almost nonfunctional all day, but the next day I wake up feeling very motivated. The Nature Made I have and most of the ones I've seen are enteric-coated, and it doesn't seem like you should be cutting those up. Still hoping to hear from @caledonia about the Hydroxy and DNA results, and she probably has some good ideas about titrating Sam-e. Thanks again for your help!
