Plasmapheresis can be highly effective in removing thrombosis, circulating cytokines, and autoantibodies, offering short-term relief and helping to reduce the overall immune load. However, the real issue often isn’t just what’s circulating in the blood — it’s that the immune system can become trapped in a chronic cytokine activation loop. Even after a plasmapheresis "cleanout," the system can reactivate and return to an inflamed state.
This pattern seems especially common in post-viral syndromes, autoimmune dysautonomia, ME/CFS, and Long COVID, where the immune response becomes self-sustaining and dysregulated.
In my personal experience, I found that a more systematic, long-term strategy to reduce cytokines was more effective. For me, using antihistamines — specifically Cetirizine — helped noticeably in modulating the inflammatory response. The first benefit I noticed was improved sleep, which I believe is essential for proper immune system recovery. The latest lab results, after years, showed improvements in IgG, IgE, and IgM levels, confirming that my approach with antihistamines has indeed had a positive impact.
) reduced cytokines and persistent inflammation. 