The biggest problem I am experiencing is the inflammatory response, Aside from keeping my PUFA and magnesium (via epsom salt baths) concentrations high, a little niacin has also been beneficial. I think niacin might have some ability to slow down the inflammatory symptoms, but I welcome any ideas or critique concerning why Niacin may be helpful. This is not going to be useful to everyone, nor would I generally recommend this, I just wanted to see if anyone had experience with this.
I mentioned before about the effects of LPS in diverting tryptophan to niacin synthesis and away from serotonin, This would globally inhibit the energy metabolism by altering the NADH/NAD ratio because more NAD reduces the availability of NADH. So in simple terms, one of the effects of the toxic part of the cell wall from this category of largely pathogenic organisms is to direct the break down of the essential amino acid tryptophan towards the synthesis of niacin. Increasing niacin concentrations reduces the capacity of NADH to donate electrons to the fundamental part of the metabolism where energy from our food is converted into chemical or usable energy by our brain, organs, muscles etc.
If one doesn't have enough NADH or ATP, he or she can develop lactic acidosis, so this has to be tightly regulated with a number of other counter-regulatory responses. An accumulation of ADP and NAD would have the effect of slowing down the energy metabolism at the most influential point. This is something seen in ME/CFS, and clearly involves multiple causes, but it appears there is a very clear way in which endotoxins could, independently execute this energy blockage, thus by design inhibiting the subservient processes of methylation and acetylation. Honestly though, I'm not sure the degree to which this would affect the PDC and energy synthesis, but this would intervene at what what happens to be the fundamental metabolic intersection. It is one way that our bodies could transiently, and without harm, inhibit energy synthesis at such a root level. The place where your food energy becomes usable by the body.
If you subscribe to a bacterial pathogenesis for ME/CFS, there is yet another interesting distinction between gram negative and gram positive bacteria in how their pyruvate dehydrogenase complexes are structured. Actually, humans and gram positive bacterial metabolism are highly similar, with gram negative bacteria again being structurally distinct.
