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Staph vaccine to treat CFS??

Hipsman

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But i will try protocol to treat Staphylococcus (one Russian (Ukraine) doctor Markov said that he treat a lot of people with this protocol (without antibiotics).
Will you use staph vaccine made by Dr. Markov or Russian Staphylococcus Adsorbed Vaccine ?

Dr. Markov makes "individual" staph vaccine for every patient by using the patient’s own bacterial flora for the preperation of vaccine, at least that’s what Dr. Markov says he does. I found about Dr. Markov’s staph vaccine before this thread, but found his approach sketchy, so I did not visit his office.

One Ukrainian ME/CFS patient found that Dr. Markov’s staph vaccine greatly helped her recovery, but still his vaccine treatment feels like scam. Some of his patients say that Dr. Markov doesn’t take any responsibility if you develop severe adverse effects from his vaccine and just ignore your calls in his clinic!
 
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Hip

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Dr. Markov makes "individual" staph vaccine for every patient by using the patient’s own bacterial flora for the preperation of vaccine, at least that’s what Dr. Markov says he does.
Interesting about Dr Markov's vaccine, do you have any web links to this (which I can translate using Google)?

I am not sure if Dr Markov's vaccine would be effective for ME/CFS purpose, though. The research of Prof Gottfries indicated that it was the alpha toxoid in the vaccine that most likely was having the therapeutic effect. Alpha toxin is one of the bacterial toxins made by Staphylococcus bacteria. A toxoid is a weakened version of a toxin.

But not all Staphylococcus vaccines are based on alpha toxoid. However the Russian Staphylococcus vaccine is specifically an alpha toxoid vaccine.


The way such alpha toxoid vaccines fight Staphylococcus is by stimulating the immune system to make antibodies which target the alpha toxin made by this bacterium.

But the mechanism by which alpha toxoid vaccines help ME/CFS may be different, and may be nothing to do with fighting Staphylococcus infection. For example, this study found that alpha toxin has an effect on the vagus nerve. Now, in the vagus nerve infection hypothesis of ME/CFS, the vagus nerve plays a central role in this disease. So if the alpha toxoid vaccine is modulating the function of the vagus nerve, this might perhaps explain its benefits for ME/CFS.
 

Hipsman

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nteresting about Dr Markov's vaccine, do you have any web links to this (which I can translate using Google)?
He has allot of info on his clinic website. The vaccine is called "autovaccine ". Here is a link to info about it on his website.
It seems very interesting, but the fact that he is using vaccine that he makes himself and that it's not controlled by any agencies is scary...
 

Hipsman

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I did the 8-week protocol with Staphylococcus Adsorbed Vaccine, here is the result:
BTW, I'm using 3-level ME/CFS scale of: mild, moderate and severe to quantify improvement.
1) 08.05 - 1 injection (0.1 ml), 1 hour later felt improvement, in total: 1/6 level next day improvement.
13.05 - slowly returned to baseline over the course of the day.

2) 15.05 - 2 injection (0.2 ml)
17.05 - improved 1/8 level from baseline
20.05 - back to baseline

3) 22.05 - 3 injection (0.3 ml)
24.05 - improved 1/8 level from baseline
25.05 - back to baseline

4) 29.05 - 4 injection (0.4 ml)
31.05 - very short term improvement 1/8 level from baseline. Next mourning back to baseline
02.06 - start to notice very slight improvement that is gradual, not abrupt like all of the above.
03.06 - improved 1/8 level from baseline.
04.06 - improved 1/6 level from baseline and very significantly improved tics (I did not notice a single tic the whole day)
05.06 mourning- back to baseline, maybe a bit better, say 1/12 level from baseline. Also tics returned to baseline.

5) 05.06 evening - 5 injection (0.6 ml)
6) 13.06 - 6 injection (0.6 ml, missed dose)
7) 20.06 - 7 injection (0.6 ml, missed dose)
8) 27.06 - 8 injection (0.9 ml, missed dose)
(I messed up dosing 3 times in a row becouse of technical errors on my part, I have no words...)
04.07 - In conclusion, nothing changed since 05.06 update, I'm around baseline level.
  • The improvements were short term so it was hard to really know how big the improvement was becouse the body is used to functioning at baseline level and needs more time to "switch".
  • I also took Vitamin D3 10.000 UI daily for 1 month prior to starting staph vaccine, after 3 injection I lowered the dose to 5000 UI daily.
04.06 - improved 1/6 level from baseline and very significantly improved tics.
Originally I started having tics when I was around 7 y/o, then they disappeared and only returned after my ME/CFS unset at age 17.
Because Staph vaccine improved both ME/CFS and tics, this suggests that the "process" that triggers my tics is linked with the "process" that triggers my ME/CFS. I think this process is immune system dysfunction, so I just need to find immunomodulators that target this "process" better, so that I can gain long-term improvements.

The above paragraph is my takeaway from this experiment, I am satisfied with the result as it gives me better understanding of my condition.

I am going to continue taking 1ml of this vaccine every 10 day until in runs out (I bought 2 packs, 20 1ml ampules in total.) Some vaccine ampules have undissolved flakes floating in vaccine, this according to instruction makes them not usable, did anyone notice such flakes in their vaccine?
 
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Hip

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I am going to continue taking 1ml of this vaccine every 10 day until in runs out (I bought 2 packs, 20 1ml ampules in total.)
According to Gottfries, it can take a few months for the benefits to appear.


Some vaccine ampules have undissolved flakes floating in vaccine, this according to instruction makes them not usable, did anyone notice such flakes in their vaccine?
I seem to remember that a few ampules had a few tiny bits in them, but that was only after being in my fridge for over a year.
 

Hipsman

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Location
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According to Gottfries, it can take a few months for the benefits to appear.
in total my 2 packs of vaccive will give me around 3 mounts of supply, I might buy one more pack...
I seem to remember that a few ampules had a few tiny bits in them, but that was only after being in my fridge for over a year.
Then it seems my vaccine supplier messed something up, I'll buy from other place.
 
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Do you know why the original Staphypan Berna can’t be reproduced? I ask the gottfries clinic, but didn’t get a response.
 

Hip

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Do you know why the original Staphypan Berna can’t be reproduced? I ask the gottfries clinic, but didn’t get a response.
It is a tragedy, but due to new GMP regulations governing the manufacture of pharmaceuticals, the old process for making Staphypan could not be updated to satisfy the new regulations, so they stopped making it. And yet this was probably one of the best ME/CFS treatments available.

More info in this post.