I had a chance to listen to some excellent teachings from the PhDs about the Itaconate Pathway. For what it is worth, I thought I would break it down into simpler terms.
1/ The body produces energy through a complex biochemical process. This is also known as the Kreb's Cycle. Again, this is a very complex cycle that involves a number of raw materials to function.
2/ When this cycle is interrupted then cells cannot be efficient in performing their duties.
3/ When the cells cannot manufacture energy, then problems arise. For instance, immune cells use this cycle (as do neurological cells, skin cells etc). If the immune cells are not functioning correctly because the complex metabolic cycles are broken, then your immune system will not be robust. Copy and paste this same concept to the other cells of the body (neurological, detoxification etc.)
4/ The Itaconate Pathway is switched on by Immune activation.
5/ It is the Itaconate Pathway that disrupts the Kreb's Cycle.
6/ If the Kreb's Cycle is interrupted, then all kinds of wonky things* happen. Example, I see some pronounced cycles that occur, then disappear then reappear such as sleep (quality), circadian rhythms, energy production etc. These are from disruptive changes in the system due to some "event". The body learns this pattern then make changes to return to center.
* "wonky things" is not a scientific term :>)