Itaconate Pathway - Called a Shunt, Interrupts citric acid cycle bleeds it off into other uses so it doesn't get into ATP, its for infection fighting. Makes you tired and low energy. What if it doesn't turn off?
Issue is its not in all cells. Have to look at RNA signatures. Assay for that RNA.
Looking for a way with modelling to lock it on, why is it blocked on?
Its interesting because we know ME/CFS patients don't burn glucose and fat very well but they do burn amino acids. This pathway would explain why these don't work well but amino acids do, because Co enzyme A being used for fats and glucose.
Excited that this may be the underlying cause/initial event.
Can happen in the brain as well and if so you burn glutimate and glutimane and these are neurotransmitters, very bad thing! Likely brain fog cause.
The solution may involve inhibiting Interferon Alpha or the reason why is that being produced. Could be an systemic viral or otherwise infection.