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lizw118 What doses of citicoline and arginine pyroglutamate did you take?
I find a heaped teaspoon (5 grams) of arginine pyroglutamate works well to combat my anxiety symptoms, and I find also helps calm the "wired" feeling in the brain that you get with ME/CFS.
Arginine pyroglutamate is in my
list of anti-anxiety supplements. It is quite possible that these anti-anxiety effects of arginine pyroglutamate are mediated by its boosting effect on glutamate transporter activity, which thus reduces extracellular glutamate in the brain, that in turn lowers the activation of the NMDA receptors. NMDA overstimulation may be the cause of anxiety and "wired" symptoms.
I think I may try higher doses of arginine pyroglutamate, like say three heaped teaspoons (15 grams).
I have also been trying out higher doses of
propentofylline in the last few days. I have taken as much as 1,000 mg of propentofylline in one go. Though typically I took 500 mg daily. This more than the 100 mg that I took in my previous experiments with propentofylline.
This higher dose of propentofylline made me feel relaxed, in a comfortable, cozy way, and made me become a little more consciously aware and self aware. Consciously awareness is the very opposite of brain fog.
I am still experimenting with propentofylline. Propentofylline is not too expensive. 60 x 100 mg tablets cost around £25. So if you were to take a 500 mg daily dose, this would cost you £2 a day. That's affordable if propentofylline were to produce significant benefits, and hopefully long term benefits.
Propentofylline is sold as a veterinary medicine used to increase mental cognition in older dogs, but has been used for humans in clinical trials for a number of conditions, including vascular dementia, Alzheimer's, acute ischaemic stroke, and chronic pain syndromes (including neuropathic pain). In this
review of phase III trials, of propentofylline for Alzheimer's and vascular dementia, the propentofylline dose was 300 mg taken three times a day, 1 hour before meals.
Note: I would advise
never to take propentofylline with tea or coffee or any source of caffeine, because I found this causes adverse effects: one day I took 1,000 mg of propentofylline with my morning coffee, and within 10 minutes felt terrible: I felt oddly light headed as if my brain was not getting enough oxygen. This feeling terrible lasted for around 2 and a half hours. I realized afterwards that propentofylline, like caffeine, is a xanthine derivative, and both propentofylline and caffeine antagonize adenosine receptors. So high doses of propentofylline I think should not be taken with caffeine.