I started Fredd's protocol and rocephin injections and on day 9 of 1g I had a miraculous improvement in clarity!!!!! I could achieve clarity without the asv and slow wave sleep medications. My neurologist/systems engineer friend from UPenn told me that brain fog is from too low/high levels of glutamate. Anyway I noticed also that I had a lot of neck stiffness.
Does it alter and balance glutamate levels in the brain somehow and help neurotransmitter levels?
Just to confirm,
@physicsstudent13, are you saying that you had an injection of 1 gram of Rocephin each day, and then on the 9th day of this regimen, you had a huge reduction in brain fog, and great improvement in mental clarity?
Rocephin most certainly does alter glutamate levels in the brain: excess glutamate is continually being removed from the extracellular spaces in the brain by what are called the
glutamate transporters, which are "pumps" found in the astrocytes and other cells in the brain.
Rocephin potently boosts the number of these glutamate transporters in the brain (it increases gene expression of the glutamate transporter; in others words, making more of them).
The brain's main glutamate transporter is called EAAT2 (also called GLT-1).
This study found Rocephin increased EAAT2 expression by as much as 3 times, which is a huge increase in the numbers of these EAAT2 glutamate transporters.
This increase in number of the brain's glutamate transporters allows much more glutamate to be pumped out of the brain, which will act to reduce the high levels of glutamate that some people think is causing many of the cognitive symptoms of ME/CFS.
More info on glutamate and ME/CFS:
Dr Paul Cheney's views,
Marco's blog about glutamate causing ME/CFS symptoms, and
my post on how neuroinflammation-derived glutamate may cause generalized anxiety disorder.
Please keep us updated on your Rocephin regimen,
@physicsstudent13. Are you on just a short course of Rocephin, or are you going to be taking this antibiotic for longer periods? The two people on this thread who had this huge improvement in mental clarity from Rocephin injections found that this improvement quickly disappeared once they stopped getting Rocephin injections or IV.
So if your mental clarify disappears within a day or so of stopping Rocephin, this will confirm that it is Rocephin that is responsible for your greatly increased mental clarify.