Rewinding your biological age

[Rufous McKinney]

Did you see the dysfunction they've found in muscle.

yes!

My hip flexors are particularly weak and pathetic. My spine: yeah it hurts alot, later in the day when I"m running out of Yin. (Yang, is therefore winning)

If your spine and muscles are screaming? I'm thinking this may be fibromyalgia type stuff; however, it could also be Feeling those amyloid protein deposits/ like they hurt the adjacent cells. OUCH

My arms don't seem to experience the screaming weakness, my hip flexors feel.

 

[Rufous McKinney]

I've got the balls to try anything.

Cumin Averse- I hate the smell and therefore never tried the cumin cure

Not deployed-

most detox efforts including

zeolite- bought, it sits, thats really scary

charcoal- unopened bottle

AllThiamine: I never opened the jar, my husband consumed them.

Lymph Cleanse chinese herbs: custom blend (make me get really ill, and a giant bubble in my brain, every time after about two days and so I quit)

18 microdoses of hand raised pscillicybin I scored. (however we spell that) (my daughter wants to fix my depression)

my husband's massive vitamin stash is no longer allowed anywhere near him(he had a severe stroke and now he no longer remembers he is required to consume supplements all day long, and only perfectly organic food and pristine water in glass bottles.).

But of course we have run out of the basic Multi. And Magnesium And Vitamin D.

 

[Oliver3]

Cumin Averse- I hate the smell and therefore never tried the cumin cure

Not deployed-

most detox efforts including

zeolite- bought, it sits, thats really scary

charcoal- unopened bottle

AllThiamine: I never opened the jar, my husband consumed them.

Lymph Cleanse chinese herbs: custom blend (make me get really ill, and a giant bubble in my brain, every time after about two days and so I quit)

18 microdoses of hand raised pscillicybin I scored. (however we spell that) (my daughter wants to fix my depression)

my husband's massive vitamin stash is no longer allowed anywhere near him(he had a severe stroke and now he no longer remembers he is required to consume supplements all day long, and only perfectly organic food and pristine water in glass bottles.).

But of course we have run out of the basic Multi. And Magnesium And Vitamin D.

Haha..thanks rufous....that's pretty funny..I think we all have lists of stuff like that don't we?
Black seed oil...that stuff is amazing...cured my POTS whilst I took it.BUT and it's a big bit, I stopped taking it because it started to harden parts of my body in a strange way...I don't know why..except that it's full of omega six and nine.
The thymoquinone in it kills inflammation..for me at least but I heard it's hard on the kidneys too, so I only use it in mast cell emergencies.

I have activated charcoal...it helps slightly...worth a try.

Zeolite, not yet. It's smthg I'm not convinced of. Not a question of bravery, a question of it feels conflicting.

Just sourced some psylocibin myself!
I watched the doc on Netflix about the imperial college londontrial. I actually tried to get on that trial but m.e. got me taken out of the selection process.
One of the trial designers told me it's six years of therapy in six hours.
I'm trying to find a guide to help me through the trip.

Thiamine....yup.

Loads of other stuff probs like you.
I used to be terrified of supps, now I'm like..give me it!!!
Just sometimes I feel smthg is I herently not right

 

[Oliver3]

I"m going to ask my Chinese herbalist about whether I can tolerate the correct ginseng. It's been in my mix in the past, but that was quite a while ago. Which type I don't recall.

I generally follow his advice; he often recommends I take some other form of X or Y, due to my known intolerances and deficiencies and side effects and they always do a mix of things/ entourage effects.

Go easy, I know you have complex issues. I've needed it to get through some very challenging emotional issues but it is stimulating so you have to be careful, as always.
That said the cheapginko biloba and ginseng combo work great. I cycle them...
But the Korean high quality one..it's weird it's more taxing but also or because it more stimulating...it's made me feel great a couple of times but use sensibly.
Boron and magnesium spray help as does Dr myhills sprays to an extent.
Quercitin is great.
Black seed oil is phenomenal if you really need to stop the sympathetic drive if it gets out of hand.
It's the thymoquinone in it. I wish they could isolate that. I've found a brand with huge thymoquinone content.
But I don't overdo it just for emergencies and she. I'm having near anaphylaxis like feelings.of course I use hydration packets too.
So much stuff just to stand still..but it needs to be done for the time being

 

[Oliver3]

we also lose our subcutaneous fat deposit integrity via the break down of proteins in the fat deposit (my personal theory)

Listen to Jen brea. I thank God she's taken this tac with tissue integrity etc

 

[Rufous McKinney]

Listen to Jen brea

I will. Thanks for reinforcing all that.

Just sometimes I feel smthg is I herently not right

I've had an interest in black seed oil (biblical references)

considered it something To Be Tried.

Well, my husband had some of that: and he had a severe stroke last year. Something was up with that black seed oil and I had reason to be concerned it might have messed with other things he was taking.

So its still here, but I'd add it to my list: Makes me Nervous

I should dig out that box and recall why was I worried? something about NO3?

 

[Rufous McKinney]

Just sourced some psylocibin myself!

during a brief investigation on what might be considered a micro dose...(most of my investigations are brief):


I ran into a research study on microdosing. So their first issue was the placebo controls. They could tell they'd been given the active substance.

Well, to me this does not sound like a micro dose.

so I think I'm going homeopathic.

 

[Violeta]

While ME/CFS patients have very different baseline levels of functionality, they all have one common clinical feature: a distinctly abnormal reaction to stressful events, termed post-exertional malaise (PEM) (Stussman et al., 2020).

Post-exertional malaise is described as an exacerbation of ME/CFS symptoms, which, in the same patient, can be triggered both by physical, cognitive, and mental exertion as well as orthostatic stress and sensory overload.

Each patient has an individual and disease severity-dependent threshold for the development of PEM.

The exercise-triggered clinical exacerbation begins after a typical delay of at least several hours post-exercise and typically persists over several days.

From: https://www.frontiersin.org/articles/10.3389/fncel.2022.888232/full

It also lists the specific and distinctive profile of clinical features of MS/CFS.

 

[Wishful]

triggered both by physical, cognitive, and mental exertion

Since mental exertion other than cognitive is a bit confusing, maybe mental stress would be a better description? That would include worry or anxiety, frightening or disturbing events, and other such stresses.

 

[SWAlexander]

My thoughts on Metformin.

Friends email me saying:
"Some with ME are on it and l have been since June but haven't noticed any difference."

My answer:
The reason you might not perceive a difference could be that Metformin suppresses the creation of new dead cells (apoptosis) but is unable to remove existing dead cells from the brain.

The accumulation of these dead cells contributes to dementia by blocking neuron function.

The best approach is to limit inflammation and remove dead cell deposits through the limbic system.

 

[SWAlexander]

Now a study is in the German medical newspaper about Metformin.

Google translation:
"Gestational diabetes: Metformin has shown little additional benefit in studies"

Excerpt:
Chapel Hill/North Carolina and Galway/Ireland – Metformin, the drug of first choice in the treatment of type 2 diabetes outside of pregnancy, only partially met expectations in 2 randomized trials in pregnant women. The primary study objectives were not achieved in both the MOMPOD study ( JAMA , 2023; DOI: 10.1001/jama.2023.22949 ) and the EMERGE study ( JAMA 2023; DOI: 10.1001/jama.2023.19869 ). An editorialist still sees possible advantages.

The specialist societies internationally agree that type 2 diabetes during pregnancy or gestational diabetes - the first exists before pregnancy, the second the blood sugar levels only rise during pregnancy - should be treated with insulin. The main reason is fundamental safety concerns, as metformin crosses the placenta and therefore enters the fetal circulation.

These concerns were put into perspective 15 years ago in the MiG study “Metformin in Gestational Diabetes”. There, 750 pregnant women with gestational diabetes whose glucose levels remained elevated despite lifestyle changes were randomized to treatment with metformin (with additional insulin if necessary) or insulin.

see provided links or read more at:
https://www-aerzteblatt-de.translat..._sl=de&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=wapp

 

[SWAlexander]

Metformin question:

https://twitter.com/i/web/status/1757425732886593641

Answer:

https://twitter.com/i/web/status/1757522163974762565

 

[Murph]

I recently read the book Lifespan by the Harvard scientist David Sinclair (an Australian, i always like to see us making a splash on the world stage!).

Now, he is overpromising. In some details he is totally full of shit. I recommend this rebuttal. But in other important ways he's right.

He conceptualises ageing as a process that increases the chance of lots and lots of diseases. It's a meta-process that if you can defeat it, reduce it or reverse it, creates a huge pan-systemic health upside.

It's about reducing the incidence of disease. When you look at it like that something flips and fighting ageing becomes a moral imperative rather than the preserve of creepy billionaires clinging to something unnatural.

Ageing does seem to vary wildly between species. Greenland sharks live for centuries. mice are lucky to make 2 years. A recent big paper by Steve Horvath did a big map of mammal lifepsans and found they can figure out an animals age by its DNA methylation status.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10501909/

"Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles.

This is expressed in safe scientific language but if you wanted to jazz it up you'd say they'd found the cause of ageing. Now they just need to figure out how to fiddle with the DNA methylation and you could be looking at longer lifespans.

(nb there are two separate parts to anti-ageing science. one is getting people closer to the max age for their species, and we have a lot of ideas about how to do that, mostly involving fasting and vegetables and not smoking. The second part is seeing if we can lift the max age for a species).

 

[SWAlexander]

if we can lift the max age for a species

Yesterday, I finished reading "Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore," leaving me to wonder who benefits from this process besides scientists inventing new ways to rearrange genetic Legos.

After reading scientific papers and books extensively for years, I have found many similar results, which leave me with several questions.

Firstly, what would be the outcome if CRISPR/Cas9, developed by Jennifer Doudna, could alter all methylated genes? It appears we cannot modify faulty genes inherited over generations.

Secondly, is there a way for those without a background in biology to avoid C. diff, rabies, Epstein-Barr virus, tick bites, Zika, Chagas disease, etc., or even to prevent sepsis while in the hospital?
Smoking is merely another scare tactic. My grandfather died at age 93, and my father at 86, having smoked their entire lives, whereas my grandmother passed away at age 65 and her mother at 46, neither of whom ever smoked.

If we could just find a way to reduce inflammation caused by viruses and bacteria, organs and the brain could function uninterrupted and without dementia.
Is there no way to avoid death? I would appreciate any means to eliminate or reduce pain and suffering during my lifespan.

 

[SWAlexander]

Study finds that COVID infection increases risk of new-onset dementia among elderly people​

The release of a study in pre-print form, pending peer review and publication in The Lancet, by investigators from the US and UK, found that COVID-19 infections among the elderly, those 60-years-of-age and older, caused a 60 percent increased risk of developing new-onset dementia (NOD) within a year of infection compared to controls without any other respiratory infections.
https://www.wsws.org/en/articles/2024/02/13/nzsh-f13.html

 

[Oliver3]

Hm so why haven't Janet and Ron tried this on Whitney? Ron is a geneticist so this is right up his alley.

Does he even know about it for a start?

 

[hapl808]

In some details he is totally full of shit. I recommend this rebuttal. But in other important ways he's right.

This is the problem with Sinclair. He's full of it - just a really good fundraiser. But on the other hand, we need funding to study these kinds of issues - so in that sense people like him are important.

 

[SWAlexander]

on the other hand, we need funding to study these kinds of issues

He strayed away from the issue ME/CFS, misguiding people.

 

[SWAlexander]

Quite a few people use Berberine instead of metformin.

Is berberine just like metformin?

Compared with metformin, berberine exhibited an identical effect in the regulation of glucose metabolism, such as HbA1c, FBG, PBG, fasting insulin and postprandial insulin. In the regulation of lipid metabolism, berberine activity is better than metformin.

Efficacy of Berberine in Patients with Type 2 Diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/​

 

[Luxintenebrislucet]

We know it's not an age disease because ME/CFS onset, although a bit poorly documented, seems to most likely occur between ages 15 and 40. We also know that women are more likely to get ME/CFS. This points to it being more likely autoimmune than anything else.

I have tried quite a few "de-aging" supplements, including a large number of antioxidants. They made my symptoms worse with few exceptions. Resveratrol in particular has been hyped quite a bit, but also made my symptoms worse.

The suramin news are from five years ago. I'd love to see it get forward, but it seems almost nobody with ME/CFS has even trialed it and its efficiency seems to be only theoretically speculated for

We know it's not an age disease because ME/CFS onset, although a bit poorly documented, seems to most likely occur between ages 15 and 40. We also know that women are more likely to get ME/CFS. This points to it being more likely autoimmune than anything else.

I have tried quite a few "de-aging" supplements, including a large number of antioxidants. They made my symptoms worse with few exceptions. Resveratrol in particular has been hyped quite a bit, but also made my symptoms worse.

The suramin news are from five years ago. I'd love to see it get forward, but it seems almost nobody with ME/CFS has even trialed it and its efficiency seems to be only theoretically speculated for now.

i think you are confusing here two different concepts: progeria for example its an aging disease, and children suffer from it and die very young: ME/CFS belongs to the few conditions where we age QUICKLY , faster as normal, and die sooner.