So far we only know for sure that eATP opens Panx1, in most cases.
I still think suramin probably directly closes Panx1, even at the dose used in the autism trial. Because that's what Naviaux said in his presentations. I'm happy to be proven wrong by @nandixon or anyone else, but I need to see their math, with sources for all the important values. So far he hasn't produced those. (And I dont blame him, I know we all have very limited energy. But when someone proposes a speculation that is pretty much the direct opposite of what one of the best researchers is saying, and what half the research points to, I think we need to at least see some sources, before we consider that notion seriously)