I've come across two over the counter supplements that inhibit the same purinergic receptors P2Y2 and P2X7 that Dr Naviaux mentions as Suramin's targets.
Further afield I've found some parents reporting benefits from these supplements for their autistic children:
Sytrinol
Kudzu
- Sytrinol is is a proprietary formula consisting of polymethoxylated flavones (PMF's) from citrus (including tangeretin), palm tocotrienols and other proprietary constituents. Flavones are antagonists of the purinergic P2Y2 receptor (1).
- Kudzu contains a number of isoflavones, including puerarin, about 60% of the total isoflavones, daidzein (an anti-inflammatory and antimicrobial agent), and daidzin (structurally related to genistein). Kudzu has been shown to be an antagonist of the P2X7 receptor (2).
Further afield I've found some parents reporting benefits from these supplements for their autistic children:
Sytrinol
I was desperate, and I gave her one capsule, 150mg, of Sytrinol. Within minutes, behavior returned to normal. One hour later, she became happy and began engaging and playing with me. Two hours later, wanted to do class with me and did her toughest one, reading. Did it excellently as well.
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Regarding our own experiment with natural antipurinergic therapy, we've been trialing Kudzu for the past three weeks and the outcome has been pretty impressive. It is still early to say but maybe this will enter the top three interventions. The first thing we noticed was the improvement in his articulation. It happened with the first a few days and soon I realized he started to sleep very well without Melatonin. I haven't seen night awake or silly giggling in the middle of the night since he started Kudzu. Most importantly the mysterious seizure-like episode has disappeared
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