POLL: CC allele in rs9557195

[nerd]

Considering the causal significance of herpes-viral infections, especially EBV, I'd be interested in the prevalence of the CC allele in CFS/ME patients (10.1111/bph.15395). This SNP determines the EBI 2 expression on lymphocytes and EBI 2 is a key pathogenic post-viral driver, though it initially plays a physiological antiviral role.

 

[Judee]

My viral test for EBV didn't show it. I also have IgM deficiency so maybe that is why. My allele is C;T and I voted above.

I did get Mono when I was 12 but that was very long ago so I have no access to the medical records to see the tests that doctor ran at that time.

 

[nerd]

My viral test for EBV didn't show it.

Do you mean EBI 2?

I did get Mono when I was 12 but that was very long ago so I have no access to the medical records to see the tests that doctor ran at that time.

Utmost unlikely that anyone runs this except for immunologists. I could also create a survey for EBI-induced proteins but I doubt anyone has results for it.

 

[Judee]

No, I meant Epstein-Barr virus (EBV). I thought in most cases that is what caused Mono but when I try to think back to how that doctor determined that, I cannot remember if he did any kind of testing--either blood or saliva.

I just can't remember how he determined that I had Mono. I remember the physical exam when he determined I had swollen glands, swollen liver and spleen, and the extreme fatigue but I also think he ran some kind of test.

 

[nerd]

Seems like there won't be any statistically significant difference to the average genome. The CC allele isn't common enough in CFS/ME patients to make any difference overall.