The thing is, your protocol doesn't need your claim that glutathione destroys mecbl to be helpful to people. I don't understand why you even bother to make the claim. It isn't supported by science.
Hi Pone,
It isn't supported by science
I can show you various studies where methyltrap symptoms show up as side effects of NAC or glutathione. That these items produce those symptoms “as side effects” at various rates and intensities is well established. What isn’t recognized is that all these symptoms are partial methylation block and methyltrap symptoms.
That is like the Hypokalemia as a side effect from CyCbl recognized in the 50s, always a side effect, never as a sign of blood tissue formation except that it is mentioned but not recognized as a flag that it is working. That also included the CyCbl “startup” effects that the AMA dismissed as placebo effect. Isn’t that comforting to know that SCIENCE thinks that B12 startup effects are all placebo, ALL IN YOUR HEAD. Do you believe that? So people having startup effects of B12 are having a placebo experience and it’s all in their head. That’s SCIENCE for you. Their significance as a group is not recognized. And from the sound of it you seem to think that only big money can do SCIENCE It’s true that science needing expensive supplies and mass spectrometers, NMRs, electron scanning g microscopes, MRI etc. can only be done by big money.
However, lots and lots of science has been done via observation. For instance watching people heal day by day in front of your eyes can be much more convincing than knowing that their MCV dropped from 100.0 to 99.9 and so they no longer have macrocytic anemia. Say what? There is lots of naked eye science. Most of it depends on clear thinking and recognizing what matters, and build valid logic structures on the data. So instead of detailing the 600+ biochemical malfunctions in the body caused by B12 and look for a different drug to “fix” each broken item, I found the forms of B12 and cofactors that restores these 600 biochemical malfunctions to a more normal state.
In the group health business there is never an assessment of the patients’ health. However, when their pharmacy bill goes down from $1500/month to $50/month, and the physician utilization falls off 90% and they go back to work that usually means they got a lot better. These are direct measures of utilization but all indirect measures of health. And the company does this for the entire group each year to calculate what the new premium is to be.
Right now people who get genuinely better from these chronic diseases are rare. In my opinion these are the people that need to be studied. You and I and everybody else here has already proven that SCIENCE has not provided them understanding of their condition or cured them of it. If it had we would not be here. We are outside the 95% mark. We are more than 2 standard deviations from “average”. 95% medicine doesn’t include us. I would have spent my life doing something other than dealing with this disease. I was all set to be an on-snow ski area photographer and a red light runner changed all that.
So perhaps “
It isn't supported by science” might be more accurately stated “it isn’t supported by science by my understanding of science which does not include an understanding of the scientific method”.
I don't understand why you even bother to make the claim.
That's obvious. John W. Campbell Jr, editor of Astounding Science Fiction and ANALOG once said "The art of science is making the obvious so to everybody." Twelve years ago, after almost 16 years of being down with severe CFS, FMS and congestive heart failure, eleven years into CHF with an 80% mortality rate in the first 10 years from diagnosis, I started looking seriously, full time, to solve this problem. Instead of assuming I came down with 20 or so disorders all at the same time I assumed that I had one thing. In December I got hit with methytrap and a more severe partial ATP block. Why? So what happened, I got told it was all in my head. I got kicked out of practices for insisting there was really something genuinely wrong and no doubt treatable. I had solved the problem for the first time in 1978-79 but nothing but liver was available. In 1987 MeCbl and AdoCbl and l-methylfolate were still not available.
You seem to think that I am here promoting or pushing or whatever a protocol. A lot of people here seem to look at this protocol has some fixed definition, something cast in concrete. Instead it is a description of a course of healing and the combinations of nutrients that promote or stop healing at various levels, body systems or whatever. I am working on a systems level understanding of ME, CSF, FMS, SACD, MS, Parkinson’s, Supra Nuclear Palsy and a few others all of which have partial methylation block, methyltrap and partial ATP block, all in different combinations and intensities and with unknown additional and/or resultant comorbidities. It appears that any of 5 or 6 or so varieties of paradoxical folate deficiency are at the most base root of all of these disorders, because of the many polymorphisms on folate affecting genes. The hypothesis follows from the pragmatic results.
When you get rid of all the labels, and look only at symptoms and so on, all of these have symptoms sets that all come from the same universe. What distinguishes them is where the worst damage is done. It’s like humans and chimps, something like 99% overlap genetically. Can you recognize the branches that go towards Parkinson’s or Supra Nuclear Palsy or MS or SACD? Why does it matter what one cause of demyelinating diseases is? Is it a major or minor contributor.? I don't know. Nobody does. That could come out of a well done double blind placebo study. Of course to replicate the results they would first have to get 100 or so people healing well with the active b12/folate protocol so they can pull the rug out from under them and prove it. Does it matter to you that some of us that today have functional malfunctions that have not yet damaged the nervous system beyond repair will have such demyelization in the next year or decade and move over to the “incurables” diseases? That’s a reason it’s good to know what CAN cause demyelization. It’s also good to know how to turn on methylation and ATP generation, breaking the 4 way deadlock on our body’s biochemistry. Those who understand the urgency of getting out of methyltrap can do so. Those that would rather tickle the dragon of methyltrap are also free to do so.
For starters, the current hypothesis, as to how/why glutathione causes methyltrap is one that has evolved over a 9 year period and something in excess of 6000 injections observed under perhaps 6 folate situations. These MeCbl injections took place in and out of methyltrap, in and out of all the various forms of paradoxical folate deficiency I have run into so far. There is zero doubt that glutathione can cause methyltrap in people who have previously had methyltrap and then intentionally healed and recovered from methyltrap. Methyltrap makes people sick, generally hard and fast. It's pretty much like flicking a switch. It isn't an easily feathered item either. It's more of a gate, on or off. I had skied the previous day and woke up terribly sick the next day with sudden onset CFS with which many here are familiar.
As CFS/FMS/ME sits on a foundation of partial methylation block, methyltrap and partial ATP block which can deadlock both methylation reactions and ATP reactions in numerous combinations of between 8 or 10 compartments (pharmacokineticly speaking) in body and CNS, anything that can start methyltrap in hours and start partial ATP block in a month or two predictably and cause additional sub acute combined degeneration damage in 2 weeks is very important. Perhaps this could allow researchers to have an animal model in which FMS, CFS and ME can be caused in weeks or months and then reversed. It would be very educational and oh so scientific to give mice CFS and FMS and cure them again.
Whether you like to believe it or not real science can be done at home. Further in my going to more than 100 doctors and read I don’t know how many thousands of journal articles, since folic acid and CyCbl are routinely thought to be fully effective B12 and folate through the past 60 years of mistaken research built on top of a fairy tower in the sky of the lab mistake that won a Nobel Prize. They have all sorts of microscopic evidence “proving” how effective CyCbl and folic acid are. All logic structures based on these are WRONG. None of these people can be trusted to do my thinking for me. They literally are incapable of understanding the problem or solution because of how they think about it. I am perfectly capable of doing my own thinking. I know and apply the scientific method. I spent my working life being hired to do the thinking for people who couldn’t. Why should I stop thinking just because I got sick. I changed my focus to solving ME, CFS, FMS, MS, Parkinson’s, SNP and so on. Not one of the 100 plus doctors I had hired to do my thinking on my health were capable of doing so by their own demonstration. So who would you hire to do your thinking for you?
The thing is, your protocol doesn't need your claim that glutathione destroys mecbl to be helpful to people
So the people being damaged by glutathione shouldn’t be told about it? Why would you want to see them continue to be damaged? Why shouldn’t they have an opportunity to heal? Without somebody outside the group think how long do you think it would take to have SCIENCE asking this question? 50 years? 100 years? Never?
Alongside my N=10 private study of glutathione was a sort of side car. The was an N=3 group that had methyltrap symptoms (CFS, FMS, ME) and were already taking glutathione or precursors that worked and were having zero success with the MeCbl, AdoCbl and Methylfolate they were taking already. They had never had startup and healing. A month after quitting glutathione they all had had startup and were actively healing, as the initial hypothesis stated. There was no need for a revised hypothesis and another iteration.
Solving the problem of CFS, ME, FMS, MS, Parkinson’s etc requires the recognition that excess glutathione could be a cause of disease for some people, that it can do serious damage.
Similar effect to taking 400mg SAMe.
