Jimbo39
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Try going to "upload a file" and see if that works.Arrrrrrrrg. Sent to cloud and pasted. Still doesn't work
There's a disorder called PKU. If I remember right people who have it can't get rid of P. They take a med called Kuvar which is BH-4. So if I take this, should it lower my P levels? Or are there other supplements that would do the trick? Oh yeah, P (or is it aspartame?) is found in protein. So I'm going to have to change my diet big time.
It is the result of a defective enzyme, phenylalanine hydrolase (PH) which converts phenylalanine to tyrosine. In a small subset of PKU patients, the enzyme is ok but there are various defects in production of the cofactor for the enzyme, BH4
You can make tyrosine and these neurotransmitters.
Is there some concentrated source of phe in your diet? Read the PKU literature to look for hidden sources of phe.
There is a condition called hyperphenyalaninaemia , essentially PKU lite, which appears to result from low (but not absent) function of the PH enzyme.
I'd be asking for a plasma amino acid test to know what is really going on in blood rather than just urine. The urine result could be due to something else (though I can't think what at the moment).
If you have done 23 and me it could be worth researching SNPs on PH.
Ok from what I understand: BH2 (is this a type of folic acid?) + DHPR =BH4. I don't know where I'm going with this other than a possible folic deficiency.
So tyrosine=dopamine? And tryptophan =serotonin?
I don't know. This is my diet:
I think I have this. Your link said people with phe levels over 120 mold/l o
http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.1972.tb01293.x/abstract
No change in the metabolic pattern was produced by pyridoxol. In striking contrast, pyridoxamine prevented the accumulation of acidic metabolites in the brains of all animals tested. We suggest that pyridoxamine phosphate and/or pyridoxamine is actively associated with the removal of excess keto acids and aldehydes from the brain.
D, L-Phenylalanine (with B6) 750 mg - 60 Caps
Product No. 00114
The L form of Phenylalanine helps support the normal production of mood-elevating chemicals in the brain such as dopamine and norepinephrine. The D form supports the normal blocking of a nervous system enzyme that amplifies pain signals. The combination of the two forms may help support normal mood and address physical discomforts. It should not be used with MAO inhibitors or tricyclic antidepressants, or by patients who have PKU or hypertension.*
Not quite. Folate and biopterin (the base structure of BH4/BH2) are related but not identical. Two enzymes are involved in regeneration of BH4, DHPR and DHFR (dihydrofolate reductase).
Here is a recent post I made on the subject.
If you find high phe and lowish tyr this does suggest you have a problem with the PH enzyme.
If your problem is with the BH4 cofactor then you would also expect to see elevated tryptophan since BH4 is a cofactor for tryptophan hydrolase which converts trp to 5HTP (5 hydroxy trp) , the first step in serotonin synthesis.
How is your thyroid? I can't get enough serotonin with low T3.This seems weird because my tryptophan seems normal but I've definitely a serotonin problem (the lowest of my neurotransmitters).
qBh2-BH2 w/DHFR-BH4-qBH2
My tyr (wait, is this tyrosine or tryptophan?) Anyway my tyrosine is 58 (28-113). Tryptophan is 45 (23-88)
This seems weird because my tryptophan seems normal but I've definitely a serotonin problem
I'm waiting for my results. Everything's so intertwined and interconnected. Accordingly to my functional doc my adrenals are "shot" so I wouldn't be supprised if it were the case with my thyroid.How is your thyroid? I can't get enough serotonin with low T3.