Well if this pans out with some sort of hypo metabolism. It is pretty hard to exercise your way out of that!
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I mean a complete (independant) replication, not from the same authors and not using the same labs
lipid groups with over 80% metabolic impact in the study.
Just got through the paper
.....Fourth: They concluded that ME is a hypometabolic state, with a profile similar to the medically recognised survival state of "dauer", which occurs when humans experience extreme circumstances where it may die if it not change its metabolism. E.g. in extremely cold conditions, or in states of extreme hunger. ME could in other words be a evolutionary conserved hypometabolic state remniscent of this, that for some reason occurs in response to other triggers together with genetic predispositions.
Premature, but can this point us in any direction in terms of treatment?
....The low sphingolipid profile in CFS appears to be an adaptive response that is opposite to the increased sphingolipids observed in metabolic syndrome (11) and the acute cell danger response (CDR) (7) and ultimately may represent a fundamental response to oppose the spread of persistent viral and intracellular bacterial infections....
I believe the subjects were from in and around Santa Rosa, CA.Hi @Ben Howell
"Eighty subjects were from California". Can we find out if there is a relationship to where the subjects lived/worked (number of months) and known government reported toxic areas?
Here is a map, that can be used to identify sources of toxic waste. The data is derived from US Gov't sources. If we were able to get a data feed from Terradex and reference it with subject self reports (geographic locations) then we could see if the toxic chemical exposures had any impact on the study participants. If there was a relationship, then we could look at specific chemicals that are detailed about each site.
Maybe Ron is already doing this research? It might be a conflict of interest, since one of the offending sites was formerly occupied by Hewlett Packard (OptoElectronic Division) located in Palo Alto, on Page Mill Road; the land is owned (maybe still is owned?) by Stanford University.