My experience on plasmalogens

[tasha]

Hi,

Dayan Goodenowe of Prodrome has done a lot of work on Plasmalogens in relation to aging/dementia. He has written a coherent book on Alzheimers. To me, who has watched a great many YouTube videos of various practitioners/researchers, Davyan Goodenowe seems more convincing than most with a testing and treatment plan to reverse low plasmalogens, or to maintain plasmalogens levels as one ages. We lose plasmalogens as we age and they cannot be replaced by diet. They seem to be necessary for brain, heart, kidney and liver health. His test is somewhat complex for the uninitiated, like me, but I have learned to understand it and its interrelated complexities.

I have done the Prodrome test on my daughter and then on myself. Both of us are taking plasmalogen precursors and also other support mechanisms, many of which I am familiar as they are taken to support mitochondrial and peroxisomal function - creatine, choline, seraphos, Alpha-Lipoic Acid, carnitine.

The test is expensive, the treatments are expensive. Prices have dropped in the last few months with hopes for more reduction as production heats up.

In both my daughter's case and my own, there has been mild/modest improvement in cognition and strength.

I am encouraged by these products and hope they help others. (I wouldn't/t necessary ascribed to the other plasmalogen precursors on the market). At least with Prodrome you can track your progress, or lack of progress, with follow-up testing.

It is worth watching or listening to Goodenowe if you are able.

Chris

Yeah. I forked out for it because of all the rave reviews from pwme on twitter.

If I had the money I would keep trying it, but it’s one of those interventions where I needed noticeable results early on to keep going. In all my years I’ve really only had that from beta blockers and peptides. I stick with other less costly supplements for the chance of 1% help, but can’t justify this. Was burned last year with a very costly year of two types of antivirals - stuck with them for a whole year and no change in my functioning, just drained my savings.

But if I were to suddenly come into money (lol) I would definitely do prodrome glia for a solid 6-12 months. The science looks interesting.

Good luck if you try it.

i dont know if this would help but i have a discount code for 25% off =DrT25

 

[elliem]

Thank you so much! I saw this on twitter and had used your discount code for my purchase! It pushed me over the edge by making if that tiny bit less expensive. I took 6 tablets loading dose until the large bottle was gone. It helped a tiny bit but I just can’t afford it ongoing now that I’m severe and not working. But I really really appreciate you making it that big more accessible to the community through your discount and advocacy! Thank you!

i dont know if this would help but i have a discount code for 25% off =DrT25

 

[Violeta]

​

Effect of Thiamine Deficiency and Thiamine Repletion on Neutral Glyceride, Total and Free Cholsterol, Phospholipids, and Plasmalogens in Rat Liver​

https://www.sciencedirect.com/science/article/abs/pii/S0022316623145445

"After a single thiamine injection, phospholipids tend to return to normal, whereas plasmalogens increase to far above normal levels. A second injection of thiamine decreases phospholipids to below normal, which then return nearly to normal. Plasmalogens return nearly to normal without fluctuating after a second thiamine injection."

This is good news. I can't afford the plasmalogen supplements.

 

[Florida Guy]

They say there is a 25% discount if you use the code DrT25 but that message is 8 months old so I'm not sure if its still good

 

[Violeta]

It's still too expensive for me.

 

[Florida Guy]

I just ordered a bottle of ProdromeGlia it was 60 soft gels for $99 and free shipping. I seem to be getting some benefit from phosphatidyl serine (sp?) so I might as well try this since many are getting benefit. They say to take 2 a day or 4 - 8 for loading. If it makes a significant difference or better, I will keep ordering it. If it just helps a tiny bit I might try shark oil. In a month or so I will give a report

 

[Florida Guy]

I just ordered a bottle of ProdromeGlia it was 60 soft gels for $99 and free shipping. I seem to be getting some benefit from phosphatidyl serine (sp?) so I might as well try this since many are getting benefit. They say to take 2 a day or 4 - 8 for loading. If it makes a significant difference or better, I will keep ordering it. If it just helps a tiny bit I might try shark oil. In a month or so I will give a report

When I used the forum search for ProdromeGlia it gave no results. Search isn't that good

 

[Florida Guy]

Preliminary report: I ordered and paid for a bottle on dec 27, it arrived jan 9. I've been using it at about 2 caps a day at night. I had not noticed much up to today but this morning I woke up feeling great. I slept better than I have in years. I took some of my usual sleep med plus the prodromeglia the night before. Today was great, I had several things planned I had to go out for and did them all feeling energetic and good.

Its way too soon to draw any conclusions, I'm sure I'm not recovered and if I do too much I will pay a price no doubt so no going for a walk or doing work in the house because I figure I used up my daily energy even though I feel fine. If it fixes my sleep I will be well satisfied but that is far from sure. I've tried things before that worked the first day or two then nothing, so I will assume that is the case until I get evidence to the contrary.

So, a positive early result, if it keeps working or does something else thats good I will report back and whether good, bad or mixed, I will give a more complete review later

 

[Violeta]

Does anyone know if we are supposed to be making our own plasmalogens?

 

[Rufous McKinney]

Does anyone know if we are supposed to be making our own plasmalogens?

Yes I think I just read that..but where?

 

[Rufous McKinney]

So, a positive early result, if it keeps working or does something else thats good I will report back and whether good, bad or mixed, I will give a more complete review later

ordered some, in shipping.

They say there is a 25% discount if you use the code DrT25 but that message is 8 months old so I'm not sure if its still good

Yes I just got the discount.

I have to pay an additional small fortune to ship it to southern Mexico.

 

[Rufous McKinney]

are supposed to be making our own plasmalogens?

online it said this:

Yes, peroxisomes are organelles that initiate the synthesis of plasmalogens, a type of glycerophospholipid. The endoplasmic reticulum completes the synthesis process.

 

[Murph]

I continue to take the shark liver oil tablets and have some ongoing upside; it is not possible to infer causation but I rode my bicycle 7.5km a couple of days ago which i haven't done for years.
--

Also this paper has come out since this thread started and it hypothesises plasmalogen issues could be part of mecfs / plasmalogen supplements could be a treatment.

Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID-19 symptoms and myalgic encephalomyelitis/chronic fatigue syndrome

Adriano Maia Chaves-Filho 1 , Olivia Braniff 1 , Angelina Angelova 2 , Yuru Deng 3 , Marie-Ève Tremblay 4

Abstract​

After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized that a significant portion of the affected individuals developed long-term debilitating symptoms marked by chronic fatigue, cognitive difficulties ("brain fog"), post-exertional malaise, and autonomic dysfunction.

The onset, progression, and clinical presentation of this condition, generically named post-COVID-19 syndrome, overlap significantly with another enigmatic condition, referred to as myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Several pathobiological mechanisms have been proposed for ME/CFS, including redox imbalance, systemic and central nervous system inflammation, and mitochondrial dysfunction.

Chronic inflammation and glial pathological reactivity are common hallmarks of several neurodegenerative and neuropsychiatric disorders and have been consistently associated with reduced central and peripheral levels of plasmalogens, one of the major phospholipid components of cell membranes with several homeostatic functions.

Of great interest, recent evidence revealed a significant reduction of plasmalogen contents, biosynthesis, and metabolism in ME/CFS and acute COVID-19, with a strong association to symptom severity and other relevant clinical outcomes.

These bioactive lipids have increasingly attracted attention due to their reduced levels representing a common pathophysiological manifestation between several disorders associated with aging and chronic inflammation. However, alterations in plasmalogen levels or their lipidic metabolism have not yet been examined in individuals suffering from post-COVID-19 symptoms.

Here, we proposed a pathobiological model for post-COVID-19 and ME/CFS based on their common inflammation and dysfunctional glial reactivity, and highlighted the emerging implications of plasmalogen deficiency in the underlying mechanisms.

Along with the promising outcomes of plasmalogen replacement therapy (PRT) for various neurodegenerative/neuropsychiatric disorders, we sought to propose PRT as a simple, effective, and safe strategy for the potential relief of the debilitating symptoms associated with ME/CFS and post-COVID-19 syndrome.

 

[Rufous McKinney]

They say there is a 25% discount if you use the code DrT25 but that message is 8 months old so I'm not sure if its still good

the discount worked for me in February 2025

 

[SqueakyPScott]

i dont know if this would help but i have a discount code for 25% off =DrT25

the discount worked for me in February 2025

This person is an affiliate and is being paid a slice of the cost for every purchase using her code. Not disclosing this is pretty unethical and against FTC rules in the US.

 

[Rufous McKinney]

but I rode my bicycle 7.5km a couple of days ago which i haven't done for years.

wonderful, @Murph

I'm trying Prodrome Glial. I started with one in the evening, and now up to 2 per day, going on 3 weeks or so.

Maybe during brief windows of perking up, I perk up a bit more. I'll hang in there for a bit.

Feeling very ambivalent at the moment about all this experimenting. I'm somewhat doing poorly at pacing, I have two young grandaughters in the house, and unexpected demands which add up to: I can't exactly do this.

I need to stop crashing so I can tell if it's helping.

 

[Rufous McKinney]

"This person is an affiliate and is being paid a slice of the cost for every purchase using her code. Not disclosing this is pretty unethical and against FTC rules in the US."


-The person has been working to find ways to get discounts for us sick people who are continuously trying to find something to help us and we receive no help, otherwise;

and that has been disclosed on numerous occasions, and I appreciate the effort getting these discounts to happen.

 

[SqueakyPScott]

"This person is an affiliate and is being paid a slice of the cost for every purchase using her code. Not disclosing this is pretty unethical and against FTC rules in the US."


-The person has been working to find ways to get discounts for us sick people who are continuously trying to find something to help us and we receive no help, otherwise;

and that has been disclosed on numerous occasions, and I appreciate the effort getting these discounts to happen.

It should be disclosed with every post or at least once per thread. I was only aware of the affiliation because of twitter. Others won't be aware as well.

 

[Rufous McKinney]

It should be disclosed with every post or at least once per thread.

could be a Pinned Tweet....

The person works really really hard to help us, and summarizes alot of valuable information. Spends many many hours a day doing so. I would not otherwise be wading through all that information.

Most of the time, I can't make it through posts longer than 4-5 sentences. I'm just not going to effectively find the Cure for Myself at this rate.

Often can't read anything more than a disjointed abstract and the supposedly there is a conclusion.

 

[junkcrap50]

"This person is an affiliate and is being paid a slice of the cost for every purchase using her code. Not disclosing this is pretty unethical and against FTC rules in the US."


-The person has been working to find ways to get discounts for us sick people who are continuously trying to find something to help us and we receive no help, otherwise;

and that has been disclosed on numerous occasions, and I appreciate the effort getting these discounts to happen.

I follow her pretty closely on Twitter and I have NEVER seen her disclose this or mention it. It's sort of obvious by her behavior and promotion, but pretty dishonest and makes you question her trustworthiness on her other recommendations.

It should be disclosed with every post or at least once per thread. I was only aware of the affiliation because of twitter. Others won't be aware as well.

Absolutely. Do you have a tweet about her connection where she admits it?

could be a Pinned Tweet....

The person works really really hard to help us, and summarizes alot of valuable information. Spends many many hours a day doing so. I would not otherwise be wading through all that information.

Most of the time, I can't make it through posts longer than 4-5 sentences. I'm just not going to effectively find the Cure for Myself at this rate.

Often can't read anything more than a disjointed abstract and the supposedly there is a conclusion.

Yes. It absolutely should be a pinned tweet if she's not going to disclose it in every tweet thread.

Yes, she's very helpful, does good work, and provides good info. But by not disclosing it, it's a huge turnoff and makes me a bit angry, even though I already highly suspected she was getting kick backs.