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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Yes, but as sublingual in that oral delivery does NOT work. Lozenges by Source Naturals have been very helpful. GABA antagonizes high glutamate which causes the anxiety, glutamate accumulates from high immune stress and/or psychological stress.thanks for the clarification!
have you experimented with GABA (γ-Aminobutyric acid)?
Thank you for looking into it. I had a muscle biopsy done previously which showed mitochondrial abnormalities and had genetic testing done which was normal. So I tried to copy the NIH study and used sodium butyrate and TUDCA for one month with no change in symptoms. So I wasn't sure if I used the ingredient they are supposedly using (sodium phenylbutyrate) that I might have different results. I would be able to access it on Mark Cubans website but the cost is $2000 for a month trial which seems like a really big investment.No, I never tried SP. I did take a look in PubMed to see if there was a study on SP and tight junction proteins, I did not see anything. There was a study on SP and spinal cord injury, something about it providing barrier integrity. Although there is not a published study does not indicate whether it works or not. Thanks for asking the question.
Thank you for the suggestions. I will look into some of your thoughts. I have been taking creatine and l-carnitine. I never tried glycine so that is something to add. I take magnesium glycinate but it’s a small dose so I doubt it makes a change. I don’t think I see any change in my muscle weakness so far with my supplements unfortunately.@BNQG2RDU For muscles, you can try a variety of different amino acids including creatine. I have been using beta Alanine along with creatine with noticeable results. BCAA (branched chain amino acids), I tried those along with glutamine as well, but results were minimal. Creatine with beta-Alanine seem to work better.
Some b vitamins help in the metabolism of aminos as do other nutrients, I am thinking magnesium, selenium et
Glycine has always helped me, but I found the supplemental form took some time to adjust, whereas just using bone stock was much better. Bone stock has glycine but also a few other aminos. I am now using beef stock vs. chicken stock as it does have more beneficial peptides in it. I mix a polyphenol blend in warmed bone stock. The polyphenol mix uses turmeric, Ceylon cinnamon and other spices, works well for the gut as well.
Glycine was always the odd one out, as mentioned, I had good success with it as bone stock but when I switched to free form glycine, initially, it caused some problems. @Mary reported some issues with it as a supplemental form and started slowly then built up, my experience with it was similar to hers.Thank you for the suggestions. I will look into some of your thoughts. I have been taking creatine and l-carnitine. I never tried glycine so that is something to add. I take magnesium glycinate but it’s a small dose so I doubt it makes a change. I don’t think I see any change in my muscle weakness so far with my supplements unfortunately.