do you have an idea on how to treat such biofilms? i've read that amylase can aide it and wheat seems to contain an amylase inhibitor.
There are many anti biofilm supplements, many are enzymes. Biofilms can vary in their constituents therefore one enzyme is unlikely to be effective IMO.
I like the Interfase products, the one without the plus ie EDTA which uses up space in the capsule and reduces the enzyme levels because of that. EDTA is cheap and I purchased some and put that into capsules to take along with Interfase (non plus). It's important not to take too much EDTA because it can affect blood cells and it can bind to minerals in the blood. I believe that the maximum is meant to be around 1.5 grams in the blood but it is not all absorbed from the digestive system. The 1.5 grams was using IV EDTA because more than that was found to be damaging.
I use 2 size zero capsules when I am working on the biofilm(s). It's very important not to take any new antimicrobials without first removing the biofilm(s) because they will adapt to any antimicrobials very quickly when they are inside a biofilm. I also add some extra Serrapeptase and Nattokinase. I do use a lot of capsules, I use around 12 decapped.
Quorum Sensing Inhibitors would also be helpful and those depend upon the microorganism(s) involved. QSI's tend to inhibit micro-organism communication within a biofilm which helps prevent them from signalling to carry out activities within the biofilm such as strengthening the biofilm when it is being broken down. They can rebuild it very quickly therefore blocking this process can be very helpful. EDTA binds to minerals such as calcium, magnesium and other metals which are released from the biofilm which helps prevent them getting the nutrients to rebuild the biofilm.
Other antibiofilm enzyme formulas in no particular order:
Interfase and Interfase plus - note that the plus is not really an advantage because the EDTA amount is too small IMO and it takes space away from the enzymes and there are less enzymes contained within it.
Biofilm Defense by Kirkman Labs
Biofilm Phase-2 Advanced (containing bismuth a known antibiofilm compound which is often used when treating helicobacter pylori.)
BioDisrupt - This looks quite poor to me.
SerraDefend
My personal rating would be Interfase (87.5mg more enzymes than the plus variety per capsule), SerraDefend, Biofilm Phase-2 Advanced and Biofilm Defense which is missing and important enzyme if used against Candida. It may possibly use an alternative enzyme. I dislike the rice products which it contains because the enzymes could potentially work on them.
BFB 1 and BFB 2 are essential oils which work as QSI and Efflux Pump Inhibitors. Ideally these would benefit from being made into liposomes so that the oils do not form clumps so that they can have a wider affect on biofilms in different locations.
Efflux Pumps are what can make pathogens resistant to antimicrobials therefore inhibiting them can make antimicrobials more effective. There are many EPI's and some in food stuffs, Green Tea contains some among many others. Particular QSI's and EPI's largely have similar effects on different microbial mechanisms affecting both Efflux Pumps and Quorum Sensing. If something is effective against an Efflux Pump then it is likely to also be effective against Quorum Sensing of the micro-organism.
Be aware that some of these products, most notedly Interfase and SerraDefend both contain Chitosanase which has been shown to be effective against Candida cell walls and Candida biofilms. Also be aware that pathogens can share a biofilm, there can be different species within a biofilm and it is not uncommon for Candida to share a biofilm with some bacteria species.
NAC also works against biofilms and might explain why many of use react badly to NAC. The dosage needs to be fairly high for maximum effect, I did seen an article on it but lost it unfortunately.
There are many other things which are effective against biofilms. There are many natural anti biofilm herbs and supplements and PubMed
Central lists quite a few of them.
