caledonia
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Just popping in so you can see my signature links.
Hello there,
This lead me to trying to figure out why I felt so great - hence my discovery of the methylation cycle.
I read Freddd’s protocol in detail, along with a couple of the others. I started taking Jarrow 5mg sublingual B12 along with the Thorne Activated B Complex. I still felt good, but ever since I increased my B12 dosage (I ended up taking 2x 5mg sublingual daily) I have crashed.
Funny you mentioned the verbal ease - that's an issue too! I do have a little hypochondria, but like you said - it's all because I have physical symptoms that haven't been diagnosed - apparently I'm as fit as a fiddle - how wrong that could be.Hey Ryan. First of all buddy if the B-Complex helped get back to it and see if it keeps helping like someone else suggested already. I have taken a couple of active B-complexes and the best one hands down was by Metabolic Maintenance. I took it sublingually for far better absorption, good stuff for mood, energy and verbal ease. Also maybe you DO have real hypochondria, so I am sorry if I just assumed doctors are pushing that to you because as you have experienced yourself they will push that systematically to anyone with a chronic illness that their tests cannot "prove". Either way you also have real physical problems so I would focus in improving those, I am sure not having symptoms would help a lot with any "health obsession" right?
EDIT: Just saw your "liquid ass" comment. Boy, do you have to start reading on "leaky gut" and take action. This is central to autoimmunity and autoimmunity is central to CFS and a lot of chronic "unexplainable" diseases. And yes leaky gut and candida are kind of best friends forever.
I grabbed some of the Solgar Chelated Zinc this morning. I've taken 44mg so far - I think I'm going to leave it at that for today. No immediate response but I'll continue taking it. Thanks for checking inOmg you are in the UK. Not a good place to be with this illness. Ryan did u try zinc ? That was a missing piece for me. Methylation didn't work for me....I got excitotoxicity. I had to stop..started zinc slowly adding Bs...& experimenting with BH4.
Hi @sregan - thanks for your comment, I really appreciate all of the support - everyone is great here.@ryanbarclay, if you can get to that place where you feel amazingly wonderful again, like you haven't felt in years... (whispering) don't make any changes!!! Enjoy, enjoy, enjoy. By all means do some research but if it ain't broke don't touch it.
If things change then start adding/taking away things. Would also recommend only adding 1 thing at a time (or 2-3 synergistic things. i.e. Zinc and P5P for pyroluria) and don't make a change for a week. Otherwise you'll never know what is helping and what is hurting.
I also vote to just go back to taking the Thorne Basic B-Complex.
The dosages in that seem pretty high for a basic B (high B1, B3 and Biotin). I doubt you are getting that much B12 from something you swallow. Your gut needs intrinsic factor to metabolize B12 going that route. I might suspect you could add some sublingual B12 to your b-complex. (nothing like the 5mg that you were taking. Maybe 200-400mcg sublingual. That would be the next thing I add to the B-Complex if you find the b-complex isn't working like it used to. Most likely you have created a deficiency somewhere.
Your potassium levels may have tanked, read freddd's posts about potassium. This can cause severe lethargy and fatigue. As things start to work better with folate andb12 it can increase the need for potassium rather quickly, causing potassium deficiency.Hello there,
It’s my first post here as I’m looking for some help and advice with regards to the methylation protocols.
I’m very new to all of this and am not fully familiar with the science behind the methylation cycle so any help, advice and tips would be greatly appreciated.
I’ve been struggling with chronic fatigue along with depression and paranoia (health paranoia) for many years. Even as a child, I was very nervous and skinny. Every morning I wake up and feel like a zombie no matter how much sleep I get and am so depressed with brain fog and memory problems.
I don’t have any issues with my nerves, no tingling, numbness, pain or anything like that.
About two weeks ago, I purchased Thorne Basic B Complex which includes the B complex in their methylated forms.
Within 3-4 days I had some AMAZING results - honestly life changing results - My depression had lifted, my brain fog was clearing, I actually felt happy and motivated and I felt that I had so much more energy and stamina in my muscles too (physical). I was running up and down the stairs, getting things done, had great motivation - it was honestly life changing. Colours seemed much more vivid, I was really appreciating the real world around me. Food tasted good, I was enjoying eating again. My night vision started to improve. I was really happy. Even my memory improved - I could remember the little things again.
This lead me to trying to figure out why I felt so great - hence my discovery of the methylation cycle.
I read Freddd’s protocol in detail, along with a couple of the others. I started taking Jarrow 5mg sublingual B12 along with the Thorne Activated B Complex. I still felt good, but ever since I increased my B12 dosage (I ended up taking 2x 5mg sublingual daily) I have crashed.
I seem to have gone back to square one - back to being depressed, brain fog, extreme morning lethargy and all of the other symptoms.
Is it possible that I have depleted my folate supply? When taking such high doses of B12, could it be the lack of folate causing the block now? Perhaps I should stop taking everything and go back to just taking the Thorne B Complex again?
I remember that one night last week, I had SO MUCH energy - I felt like a million dollars and so happy then the following morning came the crash.
I take:
5mg Methyl B12 twice daily
Thorne Basic B Complex (which includes L-5-Methyltetrahydrofolate at 400mcg per capsule) twice daily
Can anyone shed any light? What’s blocking the cycle?
You're right with the one-step-at-a-time approach. Because I'm always searching for "feeling better", it's hard to keep track on what I've been taking. Perhaps I should start a supplement diary.
This "great" feeling I mention - everything felt different - my feet no longer felt cold, I could go outside in just a jumper and not feel cold! Compared to the week before where I would be wearing three layers. I had a calming and cooling feeling over my back and shoulders - it's hard to describe.
Are there any tests, genetic or otherwise that help?
It sounds like you had a toxic exposure. Did you have a vaccination or something?However, when I was about 14 years old - all of the major fatigue issues literally happened within the space of a few days and have never left me. I remember one really bad morning where my face was very swollen (especially around the eyes).
This sounds like some major anxiety, which is actually pretty common here on PR. Peruse some of the threads on anxiety, like this one, and you'll see that a fair number of people have been able to overcome it with supplements that heal the nervous system. This is, after all, a neuro-immune illness.Half life of Olanzapine is quite long so I'd have to come off it for a good few days for an accurate test. Thing is, when I try to cut down or come off, my health obsession gets really bad I I literally panic and worry so much that I can't even physically move. I think it's going to have to be a gradual process.
Probably none. C is the major allele, and 50% of the general population is CC. So you have the normal version, and it's very unlikely that it causes any abnormalities.How much methyl folate does one require if they have MTHFS rs6495446 C CC +/+?
@drew---good question! Ask Eric what he takes (at his blog "howirecovered.com")
Cheers,
Silverseas2014