Low-dose naltrexone (LDN) - how's it working for you?

[Forummember9922]

Im about to give ldn a try and had a thought RE ldn and Agmatine, which ive been experimenting with

Just curious if Agmatine could help people with tolerance issues to LDN. Agmatine has been shown to reduce tolerance to a number of things bit also it has opioid interaction - and not sure if this would be positive, negative, or synergistic with ldn

Any thoughts @datadragon if you have time? 😬🐉

Also maybe Agmatine has similar actions as LDN mainly works by increasing endorphans:

“Agmatine reduced blood sugar levels in rats by increasing β-endorphin production by the adrenal glands. β-endorphins cause the uptake of glucose from the blood into skeletal muscle tissue [40, 12, 28]. Clinical trials will be required to repeat these results in humans.”

 

[2Cor.12:19]

My rheumatologist suggested I increase my dose from 3.5 to 4.5......I've been at the 3.5 dose since I first trialed it, and for a bout...eight years (?)

Hi @Rufous McKinney. Did you ever increase to 4.5 and did it help? Do you take it once a day?

I was on 1 mg for years and increased to 2 mg about 6 months ago, which helped a lot. But then my rheumatologist recently suggested maybe upping it. I have a new 90 day supply of 2 mg and don't want to spend more right now. I'm thinking of cutting a cap in half and taking a whole and half making it 3 mg. I'm leery of just doubling the dose to 4 mg. LDN helps a LOT with pain, POTS and mood.

 

[Judee]

I'm leery of just doubling the dose to 4 mg. LDN helps a LOT with pain

I would say to trust your own ME/CFS intuition and not the doctor who probably doesn't have ME/CFS.

 

[2Cor.12:19]

I would say to trust your own ME/CFS intuition and not the doctor who probably doesn't have ME/CFS.

Thanks @Judee - My doc is really good and leaves the dosing up to me. I just got to thinking after her suggestion that maybe a little higher dose would help more. I’ve been on LDN FOR 7 years and initially worked my way up to 4 but backed down to 1 and was on that dose for years . But I’ve had lots of medication changes since then and am wondering if 3 mg might do better. Hmmm.