Some learnings from Low Dose Nalrexone (LDN)-
Learnings from people who take LDN seem to be start low at 0.5mg and increase by that every two weeks. Some people seem to be sensitive to starting at that low a dose so start at 1mg or use VLDN (very low dose dose naltrexone or ultra low dose naltrexone). Filler is an issue and suspect that is a problem rather than the LDN itself so using sucrose, ginger or rice flour as a filler sublingual, having a pharmacy compound with olive or almond oil seems a good idea too although you wouldn’t think that would work, or compounding capsules or tablets into distilled water fortnightly and leaving the filler to settle or using a coffee filter and taking dose leaving filler separated at the bottom skimming dose from the top.
Compounding at home -
https://altarp.com/how-to-prepare-low-dose-naltrexone-ldn/
If LDN disturbs your
sleep, take it in the morning or earlier in the day. It makes no difference when you take it to the rebound effect.
If you feel low or
depressed you are probably blocking endorphins for too long so taking too high a dose.
LDN can take some time to work so stick with it “
go low and go slow” seems to be the message, and if you have side effects, it is probably working - lower the dose.
If LDN appears to
stop working you may be taking too frequently or too much. Drop a day and see what happens. As we all metabolise drugs at different rates it could be you are a slow metaboliser and LDN is not clearing your system very quickly. A day free may get LDN working better.
Sublingual - avoids the digestive tract and doses straight into the blood stream if you are worried about digestive issues. Some people do this with the home made dilution if it is small enough, but you can get the pharmacy version with just naltrexone powder, water and glycerol mostly but always ask what is in what you are receiving from pharmacies as it varies.
4.5mg doesn’t seem to be the optimum dosing target, it really may be very individual and much lower doses work.
Those who are taking LDN to deal with pain seem to do dose higher. The dosing schedule for cancer isn’t above 3mg, and may depend on what disease you have.
http://ldnnow.com/48501/90512.html
When you have been taking LDN
long term you could switch around the dosing schedule again and dose alternate days as the rebound effect increases the longer you take LDN, as well as your Immune system will hopefully be in better shape than when you started so you won’t need to take as much or as frequently so play around and find a dosing schedule that suits you. This may be why LDN appears to stop working.
A reminder how LDN works
http://ldnnow.com/48501/90412.html
Handy guides for your Doctors or prescribers
https://ldnresearchtrust.org/2020_LDN_Guides
Surgery - The LDN Trust says stop LDN two days before surgery and resume two days after you have stopped taking opioids.
Side Effects Survey by LDN Trust -
Most
sensitive people are those with ME, Fibro, POTS and Mast cell activation.
Most common conditions taking LDN - Fibro and ME.
54% had no side effects
Side effects were associated with the particular formulation of LDN (type of excipients used in capsules, liquid and tablets)
(remember these can be mitigated by changing formula -
fillers,
and lowering the dose, going low and slow)
Hope this helps.
