Low-dose naltrexone (LDN) - how's it working for you?

[Judee]

Has LDN helped you with your MCS, Anyone?

 

[Florida Guy]

I took ldn years ago long before cfs, it probably has been 15 years or so ago. It was supposed to do wonderful things for me. All it did was make my insomnia get a lot worse and its bad to this day so I'm not going to try that again

 

[SleepingGirl]

Tried LDN a year and a half ago. Was on it for around three months, but had to stop due to bad nausea that it was giving me. It also enhanced the smells of things to a gross degree and sadly still can't handle some types of honey cause it keeps reminding me of how bad it smelt. Outside of that, It did absolutely nothing for my fatigue and other symptoms. Was on 4.5mg.

 

[dankeen]

It gives me roughly 5-10% improvement. I take 10-15mg (I cut a 50mg pill in quarters) and cycle roughly 4-5 days on 3-4 days off.

 

[kushami]

I thought I was starting NAC this week, then put it aside for a few days due to nausea. Then I suddenly remembered I could start LDN.

Yay!

But, after the first dose last night, I’ve got nausea again. Should I lower my dose?

Edit: Answering own question. Will give it a day and then try lower dose.

 

[kushami]

Am now trying for the third time. Am amazed that people taking this to help with alcohol dependence take 50mg when I am struggling with 0.05mg.

I feel it is doing something positive but my bowel feels slightly inflamed (I had ulcerative colitis and several bowel surgeries so am attuned to this feeling). Am therefore also amazed that this is given to ulcerative colitis and Crohn’s patients.

So far it is not affecting my sleep except for the occasional hot flush waking me up to throw off the covers and drink a glass of water.

 

[Heart Face]

It gives me roughly 5-10% improvement. I take 10-15mg (I cut a 50mg pill in quarters) and cycle roughly 4-5 days on 3-4 days off.

I was wondering why you were taking 10-15mg? Low dose is around 4.5mg but some people take much lower doses.

You may be interested in this -

“In 1980, we began an experiment in which we injected three different dosages of Naltrexone (0.1, 1, and 10 mg/kg) on a daily basis into mice that had been inoculated with cancer cells. We had no funding at this stage, so this was all done on our own time and at our own expense. We expected that the mice receiving the higher dose of Naltrexone would develop fewer tumors than those on the lower doses. After all, Naltrexone is an opioid antagonist that is far more potent and long-lasting than naloxone - and we already had great success with naloxone as an anticancer agent. However, much to our surprise, we discovered that the animals getting the 10 mg/kg each day were coming down with tumors far earlier than the controls. Yet there were no tumors in the group of mice receiving 0.1 mg/kg! One month after tumor injection all of the mice in the 10 mg/kg group and control group had tumors, but none of the mice in the 0.1 mg/kg group. By two and a half months, still only one-third of the mice in the 0.1 mg/kg group had a tumor. Mice receiving 10 mg/kg survived for a significantly shorter time than control animals. Among mice in the 0.1 mg/kg group that developed a tumor, these animals had a survival time of almost 50% longer than controls.”

https://www.ldnscience.org/resources/interviews/interview-ian-zagon

 

[eucatatrophe]

Seemed to work pretty well at 1.5mg but tritrating up has made me worse

 

[fredam7]

it freaks me out, I resisted the drs trying to give it to me, I then accepted if they would cut the dose in half, I dont sleep but I am pretty sure it kept me up all night. The reviews are all over the map. it is near impossible to know and some report horrible long term issues. I would like to jump in but my bottle sits here

 

[kushami]

Oops, I goofed. I was taking half a milligram, 0.5mg, not 0.05mg.

Don’t put me in charge of any space probes!

Am thinking of retrying at 0.25mg. It was helping my cognitive and emotional stability. I have 1mg capsules from the compunding chemist and no patience for fiddling with them to make smaller doses though. But the prescription cost a fair bit, so I hope my thrifty genes will win out.