Rufous McKinney
Senior Member
- Messages
- 14,222
Paywalled info : that seem like a huge issue given AI can't access it legally.
Link: Glutathione Depleted by Chronic Illnesses
- Thread starter linusbert
- Start date
-
- Tags
- glutathione
Well, it seems clever enough to protect itself.
Even some scientist use Sci-hub, if they don't have access to a non-subscribed journal.
Also, the 'place-holder' made up PubMed links are actually a clever way to save on electricity, for such a free-ride user, as me. As probably most. Clearly my fault if I let myself be fooled.
And I hope such incidences will make every one more critical of AI articles, without checking the key sources of important statements.
Could be theory, could be in test-tube unrealistic to the human body milieu, could be in specific animals (where each species might differ), could be observational, too short term RCT or Meta analysis (cherry-picking, what is included). Without discernment, one is bound to be fooled. And thereby others too.
By the way diet changes never seem to have been quantified for percentage increase of GSH, here they are (and I'm sure perplexity forgot to mention some, for saving electricity):
Rufous McKinney
Senior Member
- Messages
- 14,222
AI decided it feels bad about all that Methane spewing in Memphis Tennessee. Why hunt for extra references?
First, for years, I tried hard to get as much as possible from regular meals. Brassica and Allium veggies, other fruit and veggies. Mushrooms too. Which I all actually enjoy eating. But many other things too (eggs, fish, offal, cheese, nuts, overwhelmingly many varying veggies and fruits, kimchi, natto, curd, legumes... on and on), with simply not enough space in my belly for even a fraction, of it all.
Therefore, I increased to supplemental extracts, wherever possible. My other dietary intake through the years still decreased, though. Must have something to do with nutrient density. Unintentional CRON (calorie restriction with optimal nutrition), in the end?
1.4 g of various allium extracts, 1 g extracts of berries, 1 g of Triphala fruits extracts
, curcumin and pomegranate at 0.9 g each, tea. pomegranate, brassicas and mushrooms at 0.8 g each, olives at 0.7 g, and finally milk thistle at 0.4 g only (rounded averages, all as extracts), to name well dosed and known.1g of myrrh , 0.7 g of guduchi, 0.6 g of ashwagandha, 0.5 g of arjuna, brahmi and boswellia extract each, are probably lesser known outside of Ayurveda. Which works - just as my body operates - through synergy of all co-factors. Rather than the naturally lesser strength of one remedy alone. Beside too many others, cumin extract at 15 mg too, for example.
Interestingly, I lost taste for dietary garlic and berries by such supplementation after some years. And can therefore enjoy more of those, without extracts available. Onions and dark chocolate, for example. Most plant extracts had pretty constant intake. However, garlic extract intake fluctuated most. With the highest regular garlic extract correlated to the PAD remission, and highest aged garlic extract correlated to the PEM remission. Which more likely might just be a coincidence, considering the multitude of synergistic effects of such varied nutrient-dense diet and supplementation.
Last edited:
linusbert
Senior Member
- Messages
- 1,659
ai said it like this:
The 27% increase in glutathione levels is often cited from a 2009 study:However, the specific data point about glutathione is more likely derived from a follow-up or related study:
more specific explanation:
In that study, marathon runners who consumed 1–1.5 L of non-alcoholic beer daily for 3 weeks before and 2 weeks after a marathon had:
The exact value "27%" is likely a mean increase reported in the intervention group compared to control, based on the measured plasma glutathione. But:
- Lower markers of inflammation (e.g., IL-6),
- A reduced incidence of post-race respiratory infections,
- And an increase in plasma glutathione levels.
The exact value "27%" is likely a mean increase reported in the intervention group compared to control, based on the measured plasma glutathione. But:
- The study had a limited sample size (approximately 150 participants in total, divided into groups),
- There is variability across individuals,
- The result is context-dependent (i.e., high oxidative stress due to endurance exercise).
Evaluation:
- Precision: Reporting an exact "27%" increase can be misleading without confidence intervals or standard deviations. In scientific contexts, such precision suggests either a simplified or cherry-picked presentation.
- Generality: The effect was studied in a specific population (trained endurance athletes) under specific stress conditions (marathon running). It does not generalize to sedentary or non-athletic individuals.
- Reproducibility: As with most nutrition-related studies, independent replication is essential, and as of now, such replication is limited.
fun fact, i did read yesterday in the Bible that Apostle Paul recommends his son in faith Timothy to not only drink water but also a little wine because he seams to be often sick.
from 1. Letter to Timothy
coincidentally i started eating a lot of broccoli recently, like almost daily
I tried to find a scientific reference for Patrick's claim, that B-vitamins do protect from moderate alcohol use.
After all, he survived for decades an initial extremely high CAC score, otherwise a sure early death sentence. While has a boatload of otherwise unknown cited science on his site. But in this case, his reasoning is based purely on conjecture.
So I asked perplexity.ai (really saves its electricity use on me now, had to repeat my question multiple times, till it included all of them), The protective effects of high dose B-vitamins simply has never been tested in moderate alcohol use. But..
Years ago I tried a bid of wine deluded with much water against my PAD. Instantly raised liver-enzymes, already not in the optimal range due to a former NAFLD. Guess it's time to try again, now where all my Bs have been optimized in intake for years.
Initially my favorite, too. But preparing one flower, I then ended up eating broccoli for 3 days (for having something more than broccoli alone). Now I mostly use small portions of various Brassicas pickled daily.
Last edited: