Kathevans
Senior Member
- Messages
- 689
- Location
- Boston, Massachusetts
So, the past couple of days I’ve been trying to formulate a question. Something’s up, but what?
I’ve been patiently moving through the oxalate dumping for the last three months—daily diarrhea—really—and it seems suddenly to have slowed down. Two days ago I had an incredibly productive day; I even took a walk after dinner, something I haven’t done in a long time. Yesterday I was in the pits of depression, weepy, the works, and last night, despite my exhaustion, I slept two hours, then was wide awake. A half an Ambien did nothing for me. It was 7 a.m. before I finally drifted off for another hour and half. And that was it.
Eventually I crawled out of bed, but two hours later you could bounce me off the walls. I feel giggly. Ridiculous. But physically exhausted and in pain. Of course.
In my sleepless miasma last night, I went over some of the threads here—there’s so much it’s hard not to feel overwhelmed—but I came back to this very one in which @Sherpa said he has had bad experiences with Methylfolate, as I did, myself, last year.
I’ve always loved the Coenzyme B-Complex by Country Life and have taken it for years. But last year as I looked over my supplement list prior to each doctor’s visit, I noticed that between February and June, the Folate (as folic acid) had changed to Folate as Methyl-tetrahydrofolate-glucosamine salt) The same formulation that effected me so strongly when I took 1/10 of a tablet seven times on and off over a two week period (up and down, sleepless, on and on) last spring. (I called the company to confirm that this is exactly when the change occurred.)
A bit foolishly, I didn’t make the connection. Even as my trapezius muscles became hard knots, even as a pain settled in along my neck around Thanksgiving and has stayed on (even as my nose began to drip, etc). Occasionally I thought maybe the symptom had to do with methylation issues, but I wasn’t sure how to resolve that and held my course. Besides, maybe the pain had to do with the oxalates. That was a possibility, right? And just this week I was thinking it must be the ZINC SULFATE drops I’d titrated up to about 15 mgs of zinc per day. Some people don’t do well on zinc ( I’m very familiar with paradoxical reactions), and I’ve since read that sulfate isn’t the best form for absorption. Well, I stopped it but so far my sleep hasn’t improved—if anything I was feeling more of an edge of anxiety than I have for a while (Homozygous ACE!)
Then this week as the oxalate dumping slowed, the sudden good day, followed by a very bad one, then the sleepless night and with the realization that the neck was worse, I put things together. Is it possible it’s something like what @Freddd calls an “Induced and/or Paradoxical Folate Deficiency or Insuffiency” or, a “Methyl Trap”? I’m not homozygous MTHFR, but I am heterozygous—and have plenty of COMT, CBS, MTRR, NOS and PEMT…etc. Enough hobbling and you’re likely to stumble.
Maybe in some way the oxalate issue masked the real issue in some way, maybe the effects of actually absorbing/not managing to absorb the B-vitamins are only now becoming more apparent.
What do you think?
I’m thinking: so much for the NutrEval Test in December, taken when I was on my highest oxalate diet ever! So much for the OAT test I just took this week still taking the B-Multi because my doc said to stay on it so we could see where my body was with the supp. So far at least, it seems I’ll have a very poor idea of what my B-levels actually are.
Oh well.
I’m so grateful to all of you who, like me, have been willing to use your bodies as a chemistry lab. Keep on experimenting!
I’ve been patiently moving through the oxalate dumping for the last three months—daily diarrhea—really—and it seems suddenly to have slowed down. Two days ago I had an incredibly productive day; I even took a walk after dinner, something I haven’t done in a long time. Yesterday I was in the pits of depression, weepy, the works, and last night, despite my exhaustion, I slept two hours, then was wide awake. A half an Ambien did nothing for me. It was 7 a.m. before I finally drifted off for another hour and half. And that was it.
Eventually I crawled out of bed, but two hours later you could bounce me off the walls. I feel giggly. Ridiculous. But physically exhausted and in pain. Of course.
In my sleepless miasma last night, I went over some of the threads here—there’s so much it’s hard not to feel overwhelmed—but I came back to this very one in which @Sherpa said he has had bad experiences with Methylfolate, as I did, myself, last year.
I’ve always loved the Coenzyme B-Complex by Country Life and have taken it for years. But last year as I looked over my supplement list prior to each doctor’s visit, I noticed that between February and June, the Folate (as folic acid) had changed to Folate as Methyl-tetrahydrofolate-glucosamine salt) The same formulation that effected me so strongly when I took 1/10 of a tablet seven times on and off over a two week period (up and down, sleepless, on and on) last spring. (I called the company to confirm that this is exactly when the change occurred.)
A bit foolishly, I didn’t make the connection. Even as my trapezius muscles became hard knots, even as a pain settled in along my neck around Thanksgiving and has stayed on (even as my nose began to drip, etc). Occasionally I thought maybe the symptom had to do with methylation issues, but I wasn’t sure how to resolve that and held my course. Besides, maybe the pain had to do with the oxalates. That was a possibility, right? And just this week I was thinking it must be the ZINC SULFATE drops I’d titrated up to about 15 mgs of zinc per day. Some people don’t do well on zinc ( I’m very familiar with paradoxical reactions), and I’ve since read that sulfate isn’t the best form for absorption. Well, I stopped it but so far my sleep hasn’t improved—if anything I was feeling more of an edge of anxiety than I have for a while (Homozygous ACE!)
Then this week as the oxalate dumping slowed, the sudden good day, followed by a very bad one, then the sleepless night and with the realization that the neck was worse, I put things together. Is it possible it’s something like what @Freddd calls an “Induced and/or Paradoxical Folate Deficiency or Insuffiency” or, a “Methyl Trap”? I’m not homozygous MTHFR, but I am heterozygous—and have plenty of COMT, CBS, MTRR, NOS and PEMT…etc. Enough hobbling and you’re likely to stumble.
Maybe in some way the oxalate issue masked the real issue in some way, maybe the effects of actually absorbing/not managing to absorb the B-vitamins are only now becoming more apparent.
What do you think?
I’m thinking: so much for the NutrEval Test in December, taken when I was on my highest oxalate diet ever! So much for the OAT test I just took this week still taking the B-Multi because my doc said to stay on it so we could see where my body was with the supp. So far at least, it seems I’ll have a very poor idea of what my B-levels actually are.
Oh well.
I’m so grateful to all of you who, like me, have been willing to use your bodies as a chemistry lab. Keep on experimenting!
