I recently hit a bunch of negative effects, after titrating up to only 100mg of (regular) B1, that have persisted unexpectedly for a couple months after stopping:
(1) It sniped my faltering
executive function. Going from being able to do on top-down focused tasks (blogging, light researching, online shopping) for a few hours on ~50% of days. I have ADHD-PI and cognitive issues are usually my most limiting, with ME/CFS.
(2) Made me need an
extra ~2 hours in bed/asleep, up from 10 sleep and 2 on my phone 'getting up' (12 total) to sometime 14 total. Yet a paradoxically shorter non-24-hour sleep cycle (from ~25.6 hours to ~25.1). After being on a consistent (if inconvenient) ~15 day (~2 week) repetition for 7 years (since temporarily fixing it to 24h), it's now ~20 days (~3 weeks). Which seem oddly consistent, like it's changed something at a cellular level in the astrocyctes of my SCN (brain). Although, it also makes some sense as I'm feel a more overwhelming force to go to bed or get dinner.
(3) I also have had new
joint issues flare up, as I've just posted about trying to figure out in
this thread. But I'm mostly suspicious of either iodine and/or malate (magnesium).
I've read through this thread, a few days ago, so I'm aware that you've (between you) observed B1 cause re-feeding/knock-on shortages of other metabolites. I've previously
posted in Mary's thread about phosphate (for B1 refeeding), giving me unprecedented flu-like symptoms, after trying it for my osteoporosis.
It might not have been a great plan to try it on its own. But when I last gave it a whirl, years back, I quickly added the rest of the B vitamins in afterwards, then had to stop them all, as something among them was making me progressively worst. I've avoided Bs for years, since, as too difficult. Possibly all (or most) being problematic due to my histamine intolerance, and them being produced by fermentation (as I'd read various people say, back then).
So, I wanted to give B1 a fair shot on its own, this time; I'd seen the poll (reposted on social media) about B1 mega-dosing helping most pwME/CFS (or was it this thread?). And I was groping about with already weak cognitive function, trying to find an improvement that would let me return properly to get a new round of testing done. Thankfully, I seem to have found that gain in illuminating my daily hummus supper (leaving me short on food options). Hence engaging here (and starting to pursue Genova NutrEval testing again).
But, for now, I'm wondering what mechanism(s) might be behind these effects I've had from B1? And so what (supplements) might push in the opposite direction? In terms of increased fatigue, etc. Thanks.