Molybdenum, sulfur, iron and copper are the mineral cofactors in uric acid biosynthesis.
eek
...
eliminating purine-rich foods doesn't address the real issue. Additionally, dietary sources of purines actually play very little role in purine biosynthesis.
...
Elevations in uric acid, >5.0 mg/dl are reflective of rising levels of inflammatory activity and have little if anything to do with dietary purines. Uric acid can also rise in response to mycotoxicosis, and may also be elevated with GI inflammation.
...
75% of heart disease patients will present with elevations in uric acid. However, even if all fructose and purines are eliminated from the diet, uric acid may still remain elevated. As long as systemic inflammation exists, the body will synthesize more uric acid as a needed antioxidant defense.
Additionally, if there are aberrations or expressive genetic mutations in the body's methylation cycles (such as MTHFR, MTRR, SUOX, CBS), this can alter the rate of purine and uric acid biosynthesis. The pathway to purine biosynthesis is induced from 5, 10 methylene tetrahydrofolate. This folate metabolite is directly affected by multiple methylation reactions, involving many enzymes. Considering the high prevalence of methylation cycle dysfunction, one should always give attention to this factor when uric acid is elevated. Methylation dysfunction may be a core component of cardiovascular disease because of methylation's role in homocysteine metabolism, glutathione formation and nitric oxide synthesis.
...
Both elevations and decreases in uric acid are signals of oxidative stress. One should always give attention to the multitude of factors that influence uric acid synthesis.