In light of Dr. Bruce Patterson's discovery that Maraviroc is effective in treating long-haul covid, whether caused by covid infection itself or by vaccine-induced long haul. I began searching for an herbal alternative. Japan most certainly will not start admistering an experimental treatment anytime soon.
@drob31
Extracts of the medicinal herb Sanguisorba officinalis inhibit the entry of human immunodeficiency virus-1
Jumping in here. I've been on the search for alternatives for his protocol for months. Initially interested in the zi cao, Shikonin route, but finding clean sources without PA's, heavy metals etc seems impossible.
I've managed to find a few other options that 'may' have similar functions, but I need someone smarter than me to confirm that.
From my understanding, the primary goals are:
Inhibit or tamp down fractalkine/CX3CR1 to turn off the survival mechanism, so in time the S1 carrying monocytes will go into apoptosis.
Antagonize or reduce CCR5/RANTES to prevent the non-classical monocytes from getting to the blood vessels/endothelium.
Repolarization of monocytes (to return them back to their prior states so the body has the opportunity to kill them for for good.)
To potentially raise CCL4 and T-cells at this point so they can have a proper second swing at it.
This is what I've created, I can link to resources on all of this if needed, if anyone thinks I might have something here.
CX3CL1 fractalkine reduction:
Resveratrol
Berberine
Alpha lipoic acid
Aspirin
Saffron extract
Raising CCL4
vitamin A
Raising T-Cells
Vitamin D, C
(Statin function alternative)
Ursolic acid>cathepsin B inhibition>fractalkine down regulation
Punica granatum extracts against cathepsin D
"Rosemary leaf extract" highest source of ursolic acid, down regulates cathepsin B and in turn down regulates Fractalkine.
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CCR5 antagonist (maravirac alternative)
Andrographis
Grape seed extract
Exercise
Resveratrol
Berberine
Coq10
NMN / NAD IV increasing eNAMPT (inhibiting CCR5) * this one's looking to be the most promising! Might explain why people are getting better with NAD+ IV therapy.
Monocyte repolarization from M1 to M2
Vitamin C - 500 mg, twice a day
Omega 3 - once a day
Atorvastatin or Pravastatin as prescribed
Melatonin – Two to 10mg at bedtime
Vitamin D3/K2 - 5000 IU each day (optimum Vitamin D level is 60-100)
Intravenous immunoglobulin therapy (IVIG)
AVOID:
Vitamin A may raise CCR5 receptors
Milk thistle may raise genes related to CCR5
All of these were found from rigorous reading for months, I really hope there's some value or potential to it.
