Herbal alternative to the CCR5 antagonist Maraviroc

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In light of Dr. Bruce Patterson's discovery that Maraviroc is effective in treating long-haul covid, whether caused by covid infection itself or by vaccine-induced long haul. I began searching for an herbal alternative. Japan most certainly will not start admistering an experimental treatment anytime soon.
@drob31

Extracts of the medicinal herb Sanguisorba officinalis inhibit the entry of human immunodeficiency virus-1

Abstract
Highly active antiretroviral therapy (HAART) has been successful in reducing human immu-
nodeficiency virus (HIV)-1-associated morbidity and mortality since its introduction in 1996.
However, it fails to eradicate HIV-1 infection. The high cost of life-long highly active antiretro-
viral therapy and the emergence of drug resistance among HIV-1-infected individuals have
brought renewed pressure for the discovery of novel antivirals and alternative medicines.
Traditional Chinese medicine (TCM) is a complementary and alternative medicine, and serves
as a rich resource for new drug development. Despite the almost 100 plant-derived compounds
that are in clinical trials, few targetHIV-1 infection. In this study, we discovered that Sanguisorba
officinalis extract (SOE) has anti-HIV-1 properties. Using a cell-based assay and single-cycle
luciferase reporter viruses pseudotyped with envelopes from HIV-1 or control viruses, we
found that SOE exhibited significant inhibitory ability against both CCR5 and CXCR4 tropic HIV-1
(ADA and HXB2), with respective IC50 values of 1.910.16mg/mLand 3.700.53 mg/mL.SOE also
inhibited simian immunodeficiency virus infection but failed to block vesicular stomatitis virus,
severe acute respiratory syndrome coronavirus, and influenza H5N1 pseudoviruses. Further-
more, we showed that SOE had no effect on post entry events of HIV-1 replication. Because SOE
pretreatment with the virus but not with cell lines expressing viral receptors showed the
maximal inhibitory activity, we can state that SOE probably blocks entry by acting on the viral
envelope directly. In addition, SOE was able to inhibit reverse transcriptase inhibitor resistant
viruses (K103N, Y188L, and K103N/Y188L/G190A) and a protease inhibitor resistant strain (PI-
2840).Our findings demonstrate SOE as a novel and specific entry inhibitor,which sheds light on
the discovery of anti-HIV-1 drugs from traditional herbal medicines.
Copyright ª2013, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan
 

Treeman

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Search Results - Bristol Botanicals

Directions
Shake well before use. Take 20-30 drops, three times a day or as directed by your practitioner. The best way to use liquid herbal tinctures is to put the suggested amount in a glass of water, tea, or juice and drink the entire contents. Tinctures can also be administered directly into the mouth without the assistance of water however some tinctures are unpalatable which is why most people prefer to dilute them into a beverage.

Amazon.com: Di Yu Tincture, Di Yu, Garden Burnet (Sanguisorba Officinalis) Root Liquid Extract, Herbal Supplement 2x2 oz: Health & Personal Care
 
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In light of Dr. Bruce Patterson's discovery that Maraviroc is effective in treating long-haul covid, whether caused by covid infection itself or by vaccine-induced long haul. I began searching for an herbal alternative. Japan most certainly will not start admistering an experimental treatment anytime soon.
@drob31

Extracts of the medicinal herb Sanguisorba officinalis inhibit the entry of human immunodeficiency virus-1
Very interesting especially bc it seems to cross the BBB https://pubmed.ncbi.nlm.nih.gov/18981568/