Possible combination famvir + andrographolide (for ME + LC)

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Responding to a reply on a different thread: https://forums.phoenixrising.me/thr...ccr5-antagonist-maraviroc.85084/#post-2397360

In summary: looking for ccr5 antagonists - original thread mentions a different herbal. But then I found out the below information which might be useful.

Andrographolide is a ccr5 antagonist too and works on rna viruses. Difference is it has been shown to work against SARS-COV-2 - whereas Sanguisorba officinalis doesn't seem to have that effect. Whether this makes any difference at all though isn't clear.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8619093/

Cell level explanation influenza
1651228265765.png
cell level explanation HIV
1651228302322.png

It also hits ebv
1651228337612.png

So my anecdotal experience is that even if you take covid out of the equation I experienced amelioration of fatigue (which took maybe 3-6 months of andrographis whole leaf dosing) and later on quasi remission by taking just andrographis and nothing else. I used to take 2g 3x a day. The only reason I stopped is because my canker sores got worse taking it, because andro dries the body out. But now if suspect if I combined Famvir and Andrographis whole leaf, I'd get the benefits of stopping the cankers (Anecdotal but I found that famvir stops my canker sores, either by stopping my mouth drying out or stopping it via another means) and all the above benefits.
So just a theory but I wonder if Famvir and Androgpraphis (assuming it isn't too much for the kidneys - andrographis can be quite kidney heavy) - could be a potent combination. Cost would be £250 UK to do this I reckon with low dose famvir and standard dose andrographis whole leaf.

https://www.researchgate.net/public...valuation_in_major_organ_cell_representatives

SARS-CoV-2 at 25TCID 50 was able to reach the maximal infectivity of 95% in Calu-3 cells. Post-infection treatment of A. paniculata and andrographolide in SARS-CoV–2 infected Calu-3 cells significantly inhibited the production of infectious virions with the IC 50 of 0.036 μg/mL and 0.034 μM, respectively, as determined by plaque assay. The cytotoxicity profile developed over the cell line representatives of major organs, including liver (HepG2 and imHC), kidney (HK-2), intestine (Caco-2), lung (Calu-3) and brain (SH-SY5Y), showed the CC 50 of >100 μg/mL for A. paniculata extract and 13.2-81.5 μM for andrographolide, respectively, corresponding to the selectivity index over 380. In conclusion, this study provided experimental evidence in favor of A. paniculata and andrographolide for further development as a monotherapy or in combination with other effective drugs against SARS-CoV–2 infection.

So just to summarise this is a possible alternative to maraviroc. Why Famvir? Well if ME patients did have high herpes viruses they'd need to treat them long term, or for at least a few years at low doses potentially - if they got long covid they'd need a ccr5 antagonist for a certain duration x - unknown. So the combination might stop the patients ME getting worse while still dealing with covid latency.
 
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Early startup effects of andrographis are headaches, feeling extra thirsty, dry mouth, possibly nausea and possibly an exacerbation of mild allergic symptoms or breathlessness/asthma.

These generally get a lot better after 2 weeks of dosing or go away completely. They can come back and I've never figured out why. It is possible though that metabolic processes or herpes viruses replicate which andro doesn't adequately control and famvir might help with that assuming someone could get it.

Just a thought anyway as I am still paranoid about getting rid of LC once I get it. Or should I say covid?!