Hi @
Avalon
Rich's approach is the only one to have been tested on patients albeit through a small study as such it's possibly the only methylation approach that I wouldn't define as a philosophy. You see, he didn't sell expensive supplements nor complicated tests or consultations and his interest not being commercial was directed at demystifying methylation and make it available in all its simplicity to as many PWMEs as possible.
Regarding your question about success, in the link you can have a look at the results of the study which speaks for itself
http://www.mecfs-vic.org.au/sites/w...Article-2009VanKonynenburg-TrtMethylStudy.pdf
In my own case, Rich's SMP did just what it did in that study, it raised glutathione pretty quickly but it may take up to a year to normalise the overall methylation process.
The only problem I had with the protocol was the multi he suggested (the Yasko multi) which I replaced with a cheaper multimineral only because I was sensitive to some of the nutrients and vitamins in the original one. It still worked fine for me.
The one thing I learnt is that it is important to test, I mean
functionally test (rather than testing genes/SNps), your methylation before and after.
That is either through the methylation panel suggested by Rich or at least those parameters that can tell you whether methylation is being normalised.
This is because from the tests you may find that your glutathione is now OK and methylation is fixed but your overall health still has problems.
This information is crucial because it tells you that there are other things that are contributing to your illness and you have to address those separately rather than infer that the protocol isn't working or isn't doing much.
This is how Rich himself put it:
"Even though the methylation cycle function can be brought closer to normal and glutathione can be raised in most PWMEs wth methylation treatment, the etiologies and accumulated toxins and/or pathogens in most cases will need to be treated directly and specifically as well. The particular ones differ from one case to another, but the possibilities of which I'm currently aware, based on experience with cases, are as follows: Lyme disease and coinfections; biotoxin illness, especially due to water-damage in buildings; high body burdens of toxic metals, especially mercury; entrenched viral and possibly retroviral infections that are able to hide from the immune system, such as by producing nagalase; HPU (hemopyrolactamuria, also called KPU or kryptopyroluria); serious gut dysbiosis; and deficiencies of essential nutrients."
http://forums.phoenixrising.me/index.php?threads/methylation-study-and-c4a.14633/
Best wishes.
