Have you done anything that might explain this?
I think the gradual loss of collagen (maybe its not so gradual in some of us)...its a major deal. I blame that for my lower brain stem making me possibly retarded (brain fog, and the many other issues we experience).
I get tons of "swelling" up in my throat, sinus, head...brain right there.
My husband eight years older than me, has major collagen break down and his whole body is out of alignment. The odd thing we have these similar issues when he has NO issues with ME, with immune system, he hardly ever gets sick. He has an EDS gene. He also has Scandinavian homozygous genes for strange things that seem etc affect connective tissue, which shares qualities with collagen. He has hammer toes and hands, another genetic thing.
I lost my fingerprints and can't trigger the Thumb print machine. That was quite a problem in the DMV.
And my neck is unraveling on the right side. (pop pop pop all night).
I'm badly deconditioned, but wasn't this bad up until about four years ago.
I lost alot of weight- so that maybe "explained" my tissue collapsing....such that its only recently I better understand this is a big problem.