I'm sorry for the delay and I've now read through your posts and did a little research on Evusheld. But I don't have enough science background to give an opinion on the specific questions that you asked re: Evusheld and am hoping that you can ask your doctor.
I thought the reason adjuvants were used in some cases is that mrna vaccines already create a stronger immune response in other ways. And make more of the spike protein... so the non mrna ones need adjuvants to make up for that...
As far as I know (and I am about 99% certain), the mRNA vaccines for COVID do not have any adjuvants in them. They definitely have other ingredients that can cause anaphylaxis but not adjuvants that have been added to increase the immune reaction and make them even more immuno-stimulatory. All vaccines are already immuno-stimulatory (and that is of course their purpose!) but adding known adjuvants can increase the risk even further re: triggering autoimmunity.
I guess I had considered that a possibility but a rare one! The way my mcas manifests is very severe quality of life wise, but no anaphylaxis yet.
What I said re: anaphylaxis may not pertain to you if you have never had it (but I wanted to mention it just in case).
I should update my medical alert bracelet. I have one for covid.
What do you mean that you have a Medic Alert bracelet for Covid? I think I am just not understanding and apologize if it is obvious! My Medic Alert bracelet says "Anaphylaxis Risk" and "Adrenal Insufficiency: Needs Cortef" and a few other things.
We should get epipen but it's expensive even with insurance.
EpiPens without insurance are around $600 which is insane but luckily my insurance covers mine and it is only $50 for a two pack (of the brand name EpiPen). I do not get the generic b/c it involves more steps to use and it is more complicated which wastes time in a true emergency.
It's a muscle injection but in other ways is the same as mabs... I don't know how they make the dose low enough to fit in a single muscle injection butbyeah it's two mabs
I realized after researching Evusheld, and reading the package insert online, that it is two injections given together and not an infusion. From an anaphylaxis perspective, this is much more concerning to me b/c once you have given the injections, you cannot "un-give" them. Versus with an infusion, you can start at an extremely slow infusion speed and stop the infusion the moment that there is an allergic symptom and give IV Benadryl.
It's tricky. I have pretty severe reactions to a lot of things but the research i did made me think the tradeoff with novavax and evsuheld might be worth it.
I view each of these products on a case by case basis and what is right for me might be totally wrong for another person and vice versa.
speaking of I have scig and I'm supposed to get ivig which could help protect against covid ...
I Googled this too and everything that I found said that the current supply of IVIG now has Covid antibodies in it which can provide some protection (although I assume it is much less targeted compared to something like Regeneron).
From my research (again if I understood correctly), it seems like Regeneron would be given after
someone tests positive for Covid vs. Evusheld would be given as a prophylaxis to someone who does not
have Covid and has tested negative to confirm. Is that how you understood it, too?
It appears there’s a thing called the “YTE substitution”, which in the usual protein mutation notation makes the triple substitution M252Y/S254T/T256E (hence YTE). This was found to extend dramatically the half-life of antibodies, by 2-4x. Since these are somewhat older papers, they were of course done with antibodies that had nothing to do with SARS-CoV2. The discovery with Evusheld was that the technique carried over to SARS-CoV2.
I read through this part of your links but apologize that I did not understand it and the science is way above my understanding! I still have no idea how they dramatically increased the half-life of the antibodies in Evusheld.