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At this point I don't think evusheld or novavax are terrible risks compared to other immunization treatments against covid, or compared to effects of covid itself. However I do worry about one thing. i should like to ask an immunologist or a knowledgeable patient about this: if evusheld, the combination of two monoclonal antibodies made to be long lasting in the body, happens to cause a rare side effect or mcas reaction, will that reaction last for the whole time that the antibodies remain in the body, which is longer than many mabs? Even if the side effects are rare this is the one thing that concerns me. It is a type of biologic and is degraded similar to antibodies and natural igg in the body but it is also made to be particularly long lasting , which is good for protection from covid, but I guess i worry about what it means if one is the rare person to react to it.
I know there are some other mabs using the same technology to make them longer lasting. I know there are mabs that are short lasting which everyone seems to consider safe like regeneron.
I'm curious if the long lasting aspect would make evusbeld at all risky in rare cases of reactions and how immubologist would treat this. I may start a new thread for this.
@Learner1 you seem to know a lot about immune issues as does @Hip and @pattismith . What do you guys think about the problems with long lasting mabs like evusheld... they stay in the body for awhile but does that mean the side effects would necessarily last that long or does the body just stop rejecting them at some point
Evusheld and novavax and paxlovid are the three things I'm most excited for in terms of helping prevent getting even worse from covid. But I'm very frail so I do want to make sure that I am cautious about what decisions I make even if these are safer than the other vaccines.
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I'm also more concerned with covid than evusheld, but I can be concerned about both, given how hyperreactive i am. Many things like vaccines and contrast I react to even when doctors, including me/cfs specialists, have said I'll be fine, so scrupulousness/scrupulosity? Isn't irrational totally.
The reason I asked is some of you seem to have a good understanding of a lot of immune mechanisms in particular so I thought you might know the answer to this. Not what the general side effects are or how safe evusheld is but rather what the risks of making the mabs long lasting might be if any, or if there are no risks compared to a short acting monoclonal antibody . I accept the risks are generally rare , my concern in this case is that if you have something that lasts for six months in your body and you do have a reaction, like an mcas reaction or immune intolerance of it In some ways, then would that mean you stay reacting for the whole six months? I've never had a drug that has a 90 day half life so this is a question I've never had to contemplate.
I know there are some other mabs using the same technology to make them longer lasting. I know there are mabs that are short lasting which everyone seems to consider safe like regeneron.
I'm curious if the long lasting aspect would make evusbeld at all risky in rare cases of reactions and how immubologist would treat this. I may start a new thread for this.
@Learner1 you seem to know a lot about immune issues as does @Hip and @pattismith . What do you guys think about the problems with long lasting mabs like evusheld... they stay in the body for awhile but does that mean the side effects would necessarily last that long or does the body just stop rejecting them at some point
Evusheld and novavax and paxlovid are the three things I'm most excited for in terms of helping prevent getting even worse from covid. But I'm very frail so I do want to make sure that I am cautious about what decisions I make even if these are safer than the other vaccines.
.
I'm also more concerned with covid than evusheld, but I can be concerned about both, given how hyperreactive i am. Many things like vaccines and contrast I react to even when doctors, including me/cfs specialists, have said I'll be fine, so scrupulousness/scrupulosity? Isn't irrational totally.
The reason I asked is some of you seem to have a good understanding of a lot of immune mechanisms in particular so I thought you might know the answer to this. Not what the general side effects are or how safe evusheld is but rather what the risks of making the mabs long lasting might be if any, or if there are no risks compared to a short acting monoclonal antibody . I accept the risks are generally rare , my concern in this case is that if you have something that lasts for six months in your body and you do have a reaction, like an mcas reaction or immune intolerance of it In some ways, then would that mean you stay reacting for the whole six months? I've never had a drug that has a 90 day half life so this is a question I've never had to contemplate.
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