Interesting though how you think the study has no significant data to show because it is derived from alterations in one specific department (lymphoblasts) and not others (any kind of tissue) while at the same time you find your BCAAs depleted in your blood but not in your tissues.
Inconsistent reasoning with all due respect.
Both your BCAA results and the lymphoblast results show a very small part of what is really going on of course.
I did not say the study has no significant data to show.
What I'm confused by is that both my labs AND a 55 minute metabolic test on a treadmill showed very clearly that I have extremely impaired fatty acid oxidation and preferentialyly do glycolysis, which seems to be the opposite of what this study says.
Therefore, I wondered if my muscles are doing something different than my lymphoblasts for some reason.
Unfortunately, I realize that very few other patients have had these tests to corroborate or disagree with the study results or provide any kind of further insight. I sure wish there were.
Impaired mitochondria is at the root of many serious diseases, including neurodegenerative diseases and cancer, both of which my parents succumbed to and I have already had cancer. I'm afraid I have a bias toward figuring out how to normalize dysfunctional mitochondria to improve my function as well as to avoid these other awful diseases.
As for BCAAs, I know they were depleted in both blood and urine. No idea about tissues - do you know how to test tissues for aminos? I did find, when I was deficient in isoleucine and leucine, that taking BCAAs after I had PEM could reverse PEM, and taking them before exercise could avoid PEM.
After using this strategy, along with working on increasing protein intake over a year, I found PEM to be rare and the BCAAs less effective when it happened (though glutathione, which I'm still short of is effective). My labs had changed, to the point where BCAA supplementation was no longer needed.
Of course, there's a lot of other stuff going on, both with me and in the studies.