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    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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mitochondria

  1. M

    What is the connection between orthostatic intolerance and impaired oxygen extraction?

    I often see ME/CFS patients that undergo exercise tests to be diagnosed with two problems: orthostatic intolerance (preload failure) and impaired oxygen extraction (mitochondrial dysfunction). They seem to be pretty well connected, but I've never seen anyone explaining which one is driving the...
  2. BrightCandle

    How the Krebs cycle powers life and death

    Really interesting simplifying presentation about the Krebs and energy cycle by the Royal Institute. Goes over the history of the finding for mitochondria and some of the simplified chemistry and variants of cycle.
  3. M

    Is there a way to negate the negative mitochondrial effects of antivirals?

    I'm due to start Acyclovir and from researching it seems most antivirals cause some degree of Mitochondrial Toxicity. Is there a way to avoid or negate these toxicity side effects? From this table there's a host of effects from Acyclovir: Source...
  4. C

    Red/Infrared light therapy, no equipment

    It is winter here, and on sunny days, when the midday sun streams across the carpet, I have been lying on cushions with the back of my head bathed by the sun. why? Sunlight is rich in red and infrared light preliminary research suggests these longer wavelengths of light support mitochondrial...
  5. leokitten

    If CoQ10 improves symptoms, what else should also help?

    Does anyone have any advice that if CoQ10 improves symptoms, then what else might also work, given CoQ10's actions in the cell and ME pathophysiology? If I take 1400 mg ubiquinol it takes a couple of hours to start working, but it pretty consistently helps with some of the worst ME symptoms for...
  6. Pyrrhus

    A systematic review of mitochondrial abnormalities in ME/CFS/SEID (Holden et al., 2020)

    I thought this 2020 meta-analysis from Staines and Marshall-Gradisnik had already been posted, but I must have missed it... A systematic review of mitochondrial abnormalities in ME/CFS/SEID (Holden et al., 2020) https://dx.doi.org/10.1186%2Fs12967-020-02452-3 Excerpt:
  7. Pyrrhus

    Role of mitochondria, oxidative stress & the response to antioxidants in ME/CFS: A possible approach to SARS-CoV-2 ‘long-haulers’? (Wood et al., 2021)

    From the team of Warren Tate who, I am obligated to say, comes from New Zealand: Role of mitochondria, oxidative stress & the response to antioxidants in ME/CFS: A possible approach to SARS-CoV-2 ‘long-haulers’? (Wood et al., 2021)...
  8. Pyrrhus

    A systematic review of nutraceutical interventions for mitochondrial dysfunctions in ME/CFS (Maksoud et al., 2021)

    Another literature review from Staines and Marshall-Gradisnik: A systematic review of nutraceutical interventions for mitochondrial dysfunctions in ME/CFS (Maksoud et al., 2021) https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02742-4 Excerpt:
  9. Hufsamor

    Dysregulated provisions of oxidisable substrates to the mitochondria in ME/CFS lymphoblasts (Missailidis et al., 2021)

    https://www.mdpi.com/1422-0067/22/4/2046
    • Hufsamor
    • Thread
    • bcaa daniel missailidis glutamine https://forums.phoenixrising.me/attachments/671cc7e1-ede2-4173-b943-22b8eebdf022-jpeg.41724/ mitochondria paul fisher
    • Replies: 44
    • Forum: Latest ME/CFS Research
  10. mitoMAN

    Promising Mitochondrial Peptides: SS-31 / Elamipretide + MOTS-c and Humanin

    A very very promising peptide under the name SS-31 (licensed name will be elamipretide) This peptide seems to have grabbed the attention of scientists researching a healing for mitochondrial myopathies. Ron Davis mentioned this as one possibly working peptide to help CFS patients! Randomized...
  11. Murph

    An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS patients 9/2019

    An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients Daniel Missailidis , Sarah Annesley , Claire Allan , Oana Sanislav , Brett Lidbury , Don Lewis , Paul Fisher * Version 1 : Received: 3 September 2019 / Approved: 4...
  12. A

    Ketogenic diet & mitochondria

    Asking everyones views , is ketogenic diet good for mitochondria function in general, better even than any so called normal diet which have more carbs ? I just semi-randomly read again about feeding mitochondrias, and this caught my eye : "One of its leading advocates is neurologist Jong Rho...
  13. C

    Melatonin supplementation improve mitochondrial function - more than just sleep.

    This 2019 study is free to access. Mitochondrial Dysfunction in Skeletal Muscle of a Fibromyalgia Model: The Potential Benefits of Melatonin ( https://www.mdpi.com/1422-0067/20/3/765 ) Discussion points of study - melatonin is: "useful to improve mitochondrial performance" "antioxidative"...
    • crat
    • Thread
    • 2019 antioxidant medication melatonin melatonin study mitochondria mitochondrial performance personal trial resveratrol supplement
    • Replies: 3
    • Forum: Latest ME/CFS Research
  14. MeSci

    Differentiating ME/CFS and FM re mitochondrial dysfunction

    I hope this isn't another duplication, but I can't find any threads in the latest ME/CFS research threads featuring the names of these researchers: Could mitochondrial dysfunction be a differentiating marker between Chronic Fatigue Syndrome and Fibromyalgia? Castro-Marrero J, Cordero MD...