Doxycycline as a CCI treatment: low-dose doxycycline inhibits the MMP enzymes which break down collagen and elastin in ligaments

Hip

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Yes, I saw that one. I would guess it might vary quite a lot depending on the strain? I notice that you posted about high dose fish oil reducing MMPs. I’d like to try that, but I would be concerned about it reducing NK cell function.
Reduced NK cell activity might be a consideration. Though high-dose fish oil in the form of VegEPA has been studied as an ME/CFS treatment, where it helps some patients (maybe those with CCI?).
 

percyval577

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Ik waak up
Another molecule that inhibits MMP1 is IL-1beta, as referred in this review on Vit D and autoimmunity: Dankers et al 2017, page 14
Not only is the IL-1β-induced production of tissue-degrading matrix metalloprotease 1 inhibited,
also the infiltration capacity of RA fibroblasts is reduced upon treatment with 1,25(OH)2D3 (223).