MODERATOR NOTE: THE FIRST 30 POSTS IN THIS THREAD HAVE BEEN MOVED FROM 'My fatigue is gone. My poisoned feeling, gone. PEM, what PEM?'
Hi this should make things clearer
The cannabinoid connection
In a
2019 meta-analysis with 531 patients diagnosed with major depressive disorder, curcumin showed a statistically significant decrease in depressive and anxiety symptoms. Researchers concluded that the tolerability and impressive results call for more studies to evaluate whether curcumin could be a validated addition to the standard of care in this patient population.
Like other spices such as black pepper, cinnamon, and cloves, curcumin is rich in terpene,
B-caryophyllene. Terpenes are compounds that provide plants their aroma, like fresh pine from
pinene, tropical mango from
myrcene, or soothing lavender from
linalool, as well as a distinct set of therapeutic benefits. These compounds are known to interact with the endocannabinoid system like their cannabinoid counterparts. In particular, B-caryophyllene selectively binds to cannabinoid receptor type 2 (
CB2), associated with immunity, demonstrating the potential role of curcumin in our protective shield against pathogens causing allergic rhinitis.
Studies reveal that even if you consume a reasonably high dose of curcumin, it has very low
bioavailability. This poor absorption indicates this in the small intestine and its rapid metabolization in the liver. Research is inconclusive whether curcumin could work in synergy with other B-caryophyllene, which contains compounds like black pepper. Certain media outlets and supplement companies boast the improved absorption of curcumin, but more clinical studies are needed to determine the relationship between the two. Researchers on the quest to discover how to improve curcumin's dismal bioavailability are looking at how it has been used in Ayurveda, emphasizing the entire plant rather than just one component.
I use caryophyllene (formerly known as Beta-caryophyllene) to treat my ME/CFS and I am almost completely normal now.
You have to bypass the liver so vaporisation I used at first. I now use more effective and practical subligual drops.
Please ask questions