Complete Symptom Relief and CFS Remission Since Starting Nitric Oxide Supplement

[TiredSam]

3) bloody expensive

Yep. But if they don't work I've lost a total of 40 quid on supplements in the last 2 years, as I'll stop within the first 180 pills. If they do work, as I'm currently working 10-15 hours a week when I should be working 30-40, I'm pretty sure I'll be able to increase my yearly income by the price of the pills and then some, plus have some quality of life back. I'm able to get my hands of 40 quid now, which is my maximum loss if it doesn't work.

But yes, they are bloody expensive.

 

[gregh286]

Yes, as far as I can make out the main drawbacks mentioned are:

1) The pills are pretty big, so might need a pill cutter
Youre dealing with cfs...one of the worst physical conditions known to man. I think handling a big tablet is a non issue.

2) takes about one month to work (although these are bodybuilders, so I think they are looking for different effects than us)

Where you get this data?


3) bloody expensive

£2 a day? Starbuck espresso costs more.



Unfortunately, I've fallen behind on some bills and am currently in overdraft (due to Christmas, Birthdays etc), so I can't try it yet.

Having said that, I'm expecting my money situation to improve over the next few months, so I'll keep watching this thread and hopefully try it in the summer.

 

[Battery Muncher]

Yep. But if they don't work I've lost a total of 40 quid on supplements in the last 2 years, as I'll stop within the first 180 pills. If they do work, as I'm currently working 10-15 hours a week when I should be working 30-40, I'm pretty sure I'll be able to increase my yearly income by the price of the pills and then some, plus have some quality of life back. I'm able to get my hands of 40 quid now, which is my maximum loss if it doesn't work.

But yes, they are bloody expensive.

Yeah, I think the potential gains outweigh the risks. It's certainly worth experimenting with!

@gregh286

1) Depends on the person, some people have problems taking pills in which case they may choke. In any case I pointed out that you could use a pill cutter

2) No data, we were talking about reading online reviews

3) Again, depends on a lot of things e.g. whether you are taking other supplements (adds up fast), your current financial situation (I'm in overdraft right now) etc

 

[Sasha]

I'm a very cautious person and in 2 years haven't tried any supplements, but I'm struggling to find a downside to trying this out. I checked all amazon reviews, no-one reports any side effects or unpleasantness,

If this stuff causes vasodilation in PWOI, surely there's a danger of blood pressure that's too low?

I can see this is going to be one of those 1,000-post threads!

But very interesting - thanks for posting and telling your story, @gregh286.

 

[panckage]

Additionally, "Use of this product us not recommended in individuals allergic to corn products, gluten, or citrus fruit."
]

Weird... according the 2012 box of this at least it specifically mentions it contains no wheat

 

[TiredSam]

If this stuff causes vasodilation in PWOI, surely there's a danger of blood pressure that's too low?

I can see this is going to be one of those 1,000-post threads!

But very interesting - thanks for posting and telling your story, @gregh286.

I have OI and low blood pressure. Like I said, I'm cautious and haven't decided to take them yet. I was hoping with my post to elicit critical comments like this, so thanks. I haven't seen any amazon reviewers saying it was an issue, and you'd expect a fair few of them to be sporty types with low blood pressure.

 

[adreno]

For those with POTS, there is very likely both a group with low NO and a group with high NO. I am one of those that do worse with NO boosters.

As @Sasha mentions, NO will normally lower blood pressure, so if you tend to be on the high side, you probably need more NO.

 

[ryan31337]

My blood pressure always erred.on high side 140/80 at rest. 155/90 standing. 250/100 on a vo2 max test.

@gregh286 have you made any measurements of your BP since taking this supplement?

@Skippa my usual hypertension goes for the day when I take co-codamol. I've only taken it in the presence of a migraine so I feel terrible all day regardless, might be worth taking it on a normal day to see what happens...

 

[Sasha]

I have OI and low blood pressure. Like I said, I'm cautious and haven't decided to take them yet. I was hoping with my post to elicit critical comments like this, so thanks. I haven't seen any amazon reviewers saying it was an issue, and you'd expect a fair few of them to be sporty types with low blood pressure.

I wouldn't take a healthy sportsperson with low BP as the same as a PWME/OI who has low BP as a result of dysautonomia or low blood volume (or whatever other weirdness is at play).

 

[gregh286]

If this stuff causes vasodilation in PWOI, surely there's a danger of blood pressure that's too low?

I can see this is going to be one of those 1,000-post threads!

But very interesting - thanks for posting and telling your story, @gregh286.

Hi.
Maybe increase in NO can help POTS types also. Tbh i cant answer that.

 

[gregh286]

@gregh286 have you made any measurements of your BP since taking this supplement?

@Skippa my usual hypertension goes for the day when I take co-codamol. I've only taken it in the presence of a migraine so I feel terrible all day regardless, might be worth taking it on a normal day to see what happens...

Hi.
No i havent. I'll take a few next week. I am not sure BP is good indicator of anything in cfs. Some are low....good....and high.

 

[Sasha]

Hi.
Maybe increase in NO can help POTS types also. Tbh i cant answer that.

I wonder if it's worth writing to Peter Rowe with this (or other researchers who might be interested).

I think there are limits on our knowledge and that getting open-minded specialists in ME/OI interested in this would be good. Ultimately, if this is any good, we need trials.

 

[ryan31337]

Hi.
No i havent. I'll take a few next week. I am not sure BP is good indicator of anything in cfs. Some are low....good....and high.

Thanks @gregh286 , I look forward to seeing them. Agreed but I wonder if BP stability may indicate more normal vasoconstriction and with that more normal blood volume (based on what Dr Bell states) and the clearing up of a lot of symptoms caused by hypovolemia.

At the very least I'd be happy to try this over the 2 or 3 anti-hypertensive drug combinations and all the side effects that come with that, especially as my BP is so variable. It's intriguing as so far the only explanation offered to me for our very similar BP readings is hyperadrenergic POTS, but I'm not sure that's a great fit...

 

[adreno]

I wonder if it's worth writing to Peter Rowe with this (or other researchers who might be interested).

There are quite a few studies on NO and POTS already.

Nitric Oxide deficit may play a role in POTS symptoms. Nitric Oxide (NO) is a very simple molecule whose job it is to control blood vessel size with changes in blood flow, changes in blood vessels during inflammation and blood vessel leakiness (Stewart, 2005). Some POTS patients have a deficit of nitric oxide (Stewart, Taneja, Glover & Medow, 2008.). This deficit may relate to the nitric oxide synthase molecule called nNOS, but it also has a compelling relationship with the hormone angiotensin-II.Together angiotensin-II and NO may help to regulate sympathetic nerve activity in the brain and also in certain peripheral nerves (such as the splanchnic circulation). Moreover, angiotensin-II can result in increased oxidative stress which can itself reduce NO (Dr. Julian Stewart, personal communication, November 28, 2007).

Researchers have found that NO levels can be increased by blocking the most important receptor for angiotensin-II. This may lead to treatments in the future in select groups of POTS patients.

http://dinet.org/index.php/information-resources/pots-place/pots-causes

 

[gregh286]

Thanks @gregh286 , I look forward to seeing them. Agreed but I wonder if BP stability may indicate more normal vasoconstriction and with that more normal blood volume (based on what Dr Bell states) and the clearing up of a lot of symptoms caused by hypovolemia.

At the very least I'd be happy to try this over the 2 or 3 anti-hypertensive drug combinations and all the side effects that come with that, especially as my BP is so variable. It's intriguing as so far the only explanation offered to me for our very similar BP readings is hyperadrenergic POTS, but I'm not sure that's a great fit...

Even in crash and non crash periods in past BP never moved...always 130-140 systolic. I think this CFS has more to do with small vessels....would that show on a BP monitor? I imagined BP monitor measure only main aertierial flow..

In fluge and mella hypothesis they descibe a disturbed NO function in endothelial cells.
http://www.shoutoutaboutme.com/treatments-2/cyclophosphamide-trial-for-me-gets-underway/

So...dont think BP and NO in endothelial cells has any connection?

 

[Aurator]

If you're thinking of giving L-Arginine (nitric oxide) a go, you really don't have to spend as much as these No 2 Black merchants are selling it at; you can get the stuff unbranded from many places on the net for a fraction of the price.

I tried it at a high dose for three months. It had zero effect on my symptoms.

 

[gregh286]

If you're thinking of giving L-Arginine (nitric oxide) a go, you really don't have to spend as much as these No 2 Black merchants are selling it at; you can get the stuff unbranded from many places on the net for a fraction of the price.

I tried it at a high dose for three months. It had zero effect on my symptoms.

No2 black and standard l arginine are not identical in formula by any stretch.

 

[Aurator]

No2 black and standard l arginine are not identical in formula by any stretch.

You are playing into the hands of the marketing men.

 

[gregh286]

Prehaps but at least it does what it says it should!!!
Dont mind paying for something that works.

 

[Aurator]

Prehaps but at least it does what it says it should!!!
Dont mind paying for something that works.

I'm pleased for you, honestly.
However, not all users of no.2 black have reported improvement after taking it.