Complete Symptom Relief and CFS Remission Since Starting Nitric Oxide Supplement
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Putative Prophylaxes of Aloe Vera Juice with L-arginine to Chronic Fatigue Syndrome
Akira Yagi, Suzuka Ataka
Abstract
L-Arginine is one of the most metabolically versatile amino acids. Several in vitro/in vivo experiments have indicated that exogenous L-arginine intake has multiple beneficial pharmacological and pharmaco-kinetic effects. Such effects include reduction in the risk of vascular and heart diseases and chronic fatigue syndrome. The effects of a dietary supplementation of aloe vera juice with L-arginine to chronic fatigue syndrome were demonstrated and a questionnaire was given to adult subjects. The questionnaire included 10 points regarding their mental, circulatory and muscle functions. Table 1 and 2 summarize the most noteworthy information on supplementation of aloe vera juice with L-arginine. The demonstrated benefits of aloe vera juice with L-arginine show promises to chronic fatigue syndrome in adult subjects.
Keywords
Aloe Vera Juice; L-arginine Supplement; Bioavailability; Immune Adjuvant and Natural Killer Cells Activity; Nitro Oxide Production; Questionnaire
http://easycore.org/index.php/joghr/article/view/1646
Akira Yagi, Suzuka Ataka
Abstract
L-Arginine is one of the most metabolically versatile amino acids. Several in vitro/in vivo experiments have indicated that exogenous L-arginine intake has multiple beneficial pharmacological and pharmaco-kinetic effects. Such effects include reduction in the risk of vascular and heart diseases and chronic fatigue syndrome. The effects of a dietary supplementation of aloe vera juice with L-arginine to chronic fatigue syndrome were demonstrated and a questionnaire was given to adult subjects. The questionnaire included 10 points regarding their mental, circulatory and muscle functions. Table 1 and 2 summarize the most noteworthy information on supplementation of aloe vera juice with L-arginine. The demonstrated benefits of aloe vera juice with L-arginine show promises to chronic fatigue syndrome in adult subjects.
Keywords
Aloe Vera Juice; L-arginine Supplement; Bioavailability; Immune Adjuvant and Natural Killer Cells Activity; Nitro Oxide Production; Questionnaire
http://easycore.org/index.php/joghr/article/view/1646
In my opinion, a large segment of this forum's members put way too much faith in medical studies. As far as I'm concerned, many of these studies have clearly become corrupted by pharmaceutical industry interests over the last few decades.
More and more, I tend to prefer anecdotal evidence from individuals, over double blind studies, as I feel they have less of a vested interest in the outcome. I certainly don't automatically think they are any less valid than published studies...
More and more, I tend to prefer anecdotal evidence from individuals, over double blind studies, as I feel they have less of a vested interest in the outcome. I certainly don't automatically think they are any less valid than published studies...
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I'd just like to detail my own experiments with arginine/ornithine-based supplements, experiments which have included:
Ornithine alpha ketoglutarate
Arginine alpha ketoglutarate
Arginine pyroglutamate (this one crosses the blood-brain barrier the best)
Di-arginine malate
Ornithine is converted into arginine in the body.
I found that all these arginine/ornithine-based supplements all had a significant anti-anxiety effect (and in fact I have included arginine pyroglutamate in my list of anti-anxiety supplements).
This paper on L-arginine is very interesting: it finds that L-arginine potentiates GABA synaptic transmission. So I think this means that L-arginine can be classed as a GABA receptor positive allosteric modulator, like benzodiazepines are.
When I take L-arginine-based supplements for anti-anxiety purposes, I notice that a tolerance to their anti-anxiety effects builds up after around 3 or 4 days use, which is reminiscent of benzodiazepine tolerance build-up.
The above paper found that the GABAergic modulating effects of L-arginine were independent of nitric oxide. So this effect that L-arginine has on the GABA system is in addition to L-arginine's effects on nitric oxide levels.
One very interesting thing I discovered with arginine pyroglutamate is that by snorting a tiny amount (100 mg) of arginine pyroglutamate powder into the nose, this would produce the same anti-anxiety effect as taking 3 grams of pyroglutamate powder orally.
What's more, the anti-anxiety effects of snorted arginine pyroglutamate would kick in fast, within around 20 minutes. Whereas when taking 3 grams of arginine pyroglutamate orally, it would take up to 2 hours to kick in.
Ornithine alpha ketoglutarate
Arginine alpha ketoglutarate
Arginine pyroglutamate (this one crosses the blood-brain barrier the best)
Di-arginine malate
Ornithine is converted into arginine in the body.
I found that all these arginine/ornithine-based supplements all had a significant anti-anxiety effect (and in fact I have included arginine pyroglutamate in my list of anti-anxiety supplements).
This paper on L-arginine is very interesting: it finds that L-arginine potentiates GABA synaptic transmission. So I think this means that L-arginine can be classed as a GABA receptor positive allosteric modulator, like benzodiazepines are.
When I take L-arginine-based supplements for anti-anxiety purposes, I notice that a tolerance to their anti-anxiety effects builds up after around 3 or 4 days use, which is reminiscent of benzodiazepine tolerance build-up.
The above paper found that the GABAergic modulating effects of L-arginine were independent of nitric oxide. So this effect that L-arginine has on the GABA system is in addition to L-arginine's effects on nitric oxide levels.
One very interesting thing I discovered with arginine pyroglutamate is that by snorting a tiny amount (100 mg) of arginine pyroglutamate powder into the nose, this would produce the same anti-anxiety effect as taking 3 grams of pyroglutamate powder orally.
What's more, the anti-anxiety effects of snorted arginine pyroglutamate would kick in fast, within around 20 minutes. Whereas when taking 3 grams of arginine pyroglutamate orally, it would take up to 2 hours to kick in.
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Can someone let us know how they get on, once they've tried the product in question please.
Thanks.
Thanks.
So it just takes 36 hours of starting this "MRI NO2 Black" product to get complete remission of your ME/CFS symptoms? That is pretty fast.
Can I ask, did your ME/CFS symptoms completely disappear, or is it more like 90% disappeared? And did all your ME/CFS symptoms vanish, or are there some which were not improved by this product?
Did your symptoms return roughly as rapidly as they disappeared (ie, in 36 hours) once your stopped this "MRI No2 Black"?
One thing you might like to try is taking a pure arginine alpha ketoglutarate supplement, and seeing if the benefits are maintained. If they are, then you will know that the arginine alpha ketoglutarate component of this "MRI NO2 Black" product is the one that is working for you.
Though you might have to dose arginine alpha ketoglutarate say 4 times a day to simulate the extended release tablets of your "MRI NO2 Black" product.
You can buy arginine alpha ketoglutarate powder more cheaply than your brand name product (see here).
Can I ask, did your ME/CFS symptoms completely disappear, or is it more like 90% disappeared? And did all your ME/CFS symptoms vanish, or are there some which were not improved by this product?
Did your symptoms return roughly as rapidly as they disappeared (ie, in 36 hours) once your stopped this "MRI No2 Black"?
One thing you might like to try is taking a pure arginine alpha ketoglutarate supplement, and seeing if the benefits are maintained. If they are, then you will know that the arginine alpha ketoglutarate component of this "MRI NO2 Black" product is the one that is working for you.
Though you might have to dose arginine alpha ketoglutarate say 4 times a day to simulate the extended release tablets of your "MRI NO2 Black" product.
You can buy arginine alpha ketoglutarate powder more cheaply than your brand name product (see here).
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Yes from 36 hours onwards. Once the vasodilation of the small vessels start i guess the body can clear lactate pretty quickly....not.so sure about 90% or 100% because having cfs for 3-4 years it quite hard to tell what 100% should feel like because we are so unconditioned from lack of exercise. But being able to walk 5 or 6 miles a day without PEM i would say puts me in a high place on bells scale.
I didnt try to raise HR yet to 170+ ....running etc as i am in a content place now and dont want to jeopardise that.
Normally i would have felt lactic building after a few.hundred metres.....
My symptoms are mostly fatigue...so i was mostly concered about that.
The symtoms returned after 1 or 2 days..i could feel myself going downhill so to speak. I assumed lactate just started building up again as you can feel the legs and body get heavier and heavier.
I didnt try to raise HR yet to 170+ ....running etc as i am in a content place now and dont want to jeopardise that.
Normally i would have felt lactic building after a few.hundred metres.....
My symptoms are mostly fatigue...so i was mostly concered about that.
The symtoms returned after 1 or 2 days..i could feel myself going downhill so to speak. I assumed lactate just started building up again as you can feel the legs and body get heavier and heavier.
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There maybe a secondary function at play also as it seems arginine has a effect on NK cell activity.
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.1995.tb03687.x/abstract
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-3083.1995.tb03687.x/abstract
Arginine can also improve both acute and chronic coxsackievirus B3 infections of the heart muscle (coxsackievirus B3 myocarditis), likely via its action of raising NO levels. See this mouse study.
Chronic coxsackievirus B infection of the muscles, stomach and nervous system is frequently found in ME/CFS. So arginine seems to have an antiviral or ameliorating effect in coxsackievirus B muscle infection.
What's more, this mouse study found that by inhibiting NO, coxsackievirus B3 titers actually increased, and the infection then caused more severe lesions in the heart muscle.
So in the mouse at least, increased NO definitely seems to be helpful for coxsackievirus B myocardial infections, and decreased NO makes these infections worse.
However, usually when you take antivirals for ME/CFS, it takes many months to have a noticeable effect, so I wouldn't think your very rapid remission from this arginine-based supplement in just 36 hours was due to the antiviral action. I would think it is much more likely to be due to the increased NO levels that can result from arginine-based supplements.
Dave Whitlock: Low NO Levels as the Cause of ME/CFS
Have you come across Dave Whitlock's low NO theory of ME/CFS? Whitlock proposes that ME/CFS is caused by low basal levels of NO. He points out that mitochondrial biogenesis (the creation of new mitochondria in cells) is critically dependent on NO levels.
Whitlock says that if your basal NO level is low, your cells will not be producing enough new mitochondria to replace the old decommissioned mitochondria. There is a fast turnover of mitochondria in cells, and if new mitochondria are not being created at a fast enough rate, this leads to a reduced number of mitochondria in cells.
The average lifespan of a mitochondrion in a cell is not known exactly, but thought to be around 2 to 4 weeks, although some studies indicate that mitochondrial lifespan may in fact be extremely brief, as short as a 2 days.
If the lifespan of mitochondria is just a couple of days, that would suggest that remedying low NO levels in ME/CFS patients should produce very fast improvements within a day or two, in terms of increasing the number of mitochondria in your cells — which is exactly what you found with your treatment using the NO-raising "MRI NO2 Black" product.
I like Whitlock's idea, as it would be a very elegant solution if ME/CFS were simply caused by reduced mitochondrial biogenesis due to low basal NO.
Chronic coxsackievirus B infection of the muscles, stomach and nervous system is frequently found in ME/CFS. So arginine seems to have an antiviral or ameliorating effect in coxsackievirus B muscle infection.
What's more, this mouse study found that by inhibiting NO, coxsackievirus B3 titers actually increased, and the infection then caused more severe lesions in the heart muscle.
So in the mouse at least, increased NO definitely seems to be helpful for coxsackievirus B myocardial infections, and decreased NO makes these infections worse.
However, usually when you take antivirals for ME/CFS, it takes many months to have a noticeable effect, so I wouldn't think your very rapid remission from this arginine-based supplement in just 36 hours was due to the antiviral action. I would think it is much more likely to be due to the increased NO levels that can result from arginine-based supplements.
Dave Whitlock: Low NO Levels as the Cause of ME/CFS
Have you come across Dave Whitlock's low NO theory of ME/CFS? Whitlock proposes that ME/CFS is caused by low basal levels of NO. He points out that mitochondrial biogenesis (the creation of new mitochondria in cells) is critically dependent on NO levels.
Whitlock says that if your basal NO level is low, your cells will not be producing enough new mitochondria to replace the old decommissioned mitochondria. There is a fast turnover of mitochondria in cells, and if new mitochondria are not being created at a fast enough rate, this leads to a reduced number of mitochondria in cells.
The average lifespan of a mitochondrion in a cell is not known exactly, but thought to be around 2 to 4 weeks, although some studies indicate that mitochondrial lifespan may in fact be extremely brief, as short as a 2 days.
If the lifespan of mitochondria is just a couple of days, that would suggest that remedying low NO levels in ME/CFS patients should produce very fast improvements within a day or two, in terms of increasing the number of mitochondria in your cells — which is exactly what you found with your treatment using the NO-raising "MRI NO2 Black" product.
I like Whitlock's idea, as it would be a very elegant solution if ME/CFS were simply caused by reduced mitochondrial biogenesis due to low basal NO.
Yes, it's always hard to gauge changes in your level of severity of ME/CFS.
I tend to find the ME/CFS scale of mild, moderate and severe the most useful and simple way of describing ME/CFS. Descriptions of these three levels of severity of ME/CFS are given here.
If any treatment gets you up one level of this scale (eg, say from severe to moderate, or say from moderate to mild), then I tend to think of that as major improvement in ME/CFS.
What would you say your level of ME/CFS was before taking this "MRI NO2 Black" product, and what is it afterwards?
I tend to find the ME/CFS scale of mild, moderate and severe the most useful and simple way of describing ME/CFS. Descriptions of these three levels of severity of ME/CFS are given here.
If any treatment gets you up one level of this scale (eg, say from severe to moderate, or say from moderate to mild), then I tend to think of that as major improvement in ME/CFS.
What would you say your level of ME/CFS was before taking this "MRI NO2 Black" product, and what is it afterwards?
Then it'd make sense, maybe, to purchase this cheaper product first to see if it does anything. If it does, then it might be worth purchasing the more expensive product with the slow-release. If it doesn't, you'll have spent less...
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I ordered a box from eBay, will give it a go and report back.
It is quite possible, though, that the benefits of the MRI NO2 Black supplement for ME/CFS do not come so much from its arginine alpha ketoglutarate ingredient, but more from the ActiNOS® ingredient, which the blurb says is scientifically proven to raise nitric oxide synthase (NOS) by 950%.
NOS is the body's enzyme which makes NO. The NOS enzyme makes NO starting with arginine as a raw material. So you need both arginine and NOS to produce NO.
Several body-building supplements contain this NOS-boosting ActiNOS ingredient, including these:
MRI - NO2 BLACK — ActiNOS content not given, but each 3 gram serving includes a proprietary blend of 150 mg of alpha lipoic acid + ActiNOS.
MRI - Pro-NOS — ActiNOS content not given.
Amix Nutrition - CFM Nitro Protein Isolate — contains 425 mg of ActiNOS per 100 grams of powder.
Reflex Nutrition - NOS Fusion — 1390 mg of ActiNOS per 100 grams of powder.
Pro Line Nutrition - Iso-Advanced Whey Protein Isolate — ActiNOS content not given.
Extrifit Sport Nutrition - Actinox Nitro Peptides — 1522 mg of ActiNOS per 100 grams of powder (I think).
ActiNOS is a whey-derived peptide fraction. ActiNOS was developed by a company called Glanbia Nutritionals. I think the scientific name for ActiNOS is nitric oxide peptide-47 (NOP-47). Their info page on ActiNOS / NOP-47 is here. To quote:
The study they are referring to in the above quote is this one.
NOS is the body's enzyme which makes NO. The NOS enzyme makes NO starting with arginine as a raw material. So you need both arginine and NOS to produce NO.
Several body-building supplements contain this NOS-boosting ActiNOS ingredient, including these:
MRI - NO2 BLACK — ActiNOS content not given, but each 3 gram serving includes a proprietary blend of 150 mg of alpha lipoic acid + ActiNOS.
MRI - Pro-NOS — ActiNOS content not given.
Amix Nutrition - CFM Nitro Protein Isolate — contains 425 mg of ActiNOS per 100 grams of powder.
Reflex Nutrition - NOS Fusion — 1390 mg of ActiNOS per 100 grams of powder.
Pro Line Nutrition - Iso-Advanced Whey Protein Isolate — ActiNOS content not given.
Extrifit Sport Nutrition - Actinox Nitro Peptides — 1522 mg of ActiNOS per 100 grams of powder (I think).
ActiNOS is a whey-derived peptide fraction. ActiNOS was developed by a company called Glanbia Nutritionals. I think the scientific name for ActiNOS is nitric oxide peptide-47 (NOP-47). Their info page on ActiNOS / NOP-47 is here. To quote:
The study they are referring to in the above quote is this one.
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Nope you will likely spend more. Buy the one in the OP and only if it works try the cheaper one