@calexis6666 Those headaches are the worst, I found that Ornithine and Chlorophyll helped with that for me. Keep in mind that if you have those headaches it can be a sign of PH problems as well (considering that free radicals generally cause this to begin with and when you can't get rid of them it's worse), especially if you have muscle soreness accompanying. I say this because it's highly common for those with moderate 5- Oxoprolinase deficiency (genetic glutathione deficiency) to experience these symptoms along with Anion GAP/metabolic acidosis and light/moderate hemolytic anemia. For the sake of reference (albeit a clinically understudied subject and complex issue to study because other SNPs affect the conditions behavior and activation) we can use 5- Oxoprolinase as a map for the potential issues associated with the CBS SNP if indeed we are under producing Glutathione.
Now, it's much easier for guys to figure this out through a simple CMP or blood testing because our iron should stay fairly stable and if we are experiencing anemia without internal bleeding it should signal a problem and then it's easier to gauge how severe/what the problem is once other tests are run, especially if MCV is normal and no other blood issues are indicated. For ladies though, iron storage changes and this might not be so cut and dry so the other option would be to do a UAA or urinalysis with a NutraEval Genova to see what's going on as it would save you a lot of trouble, time and experimentation. If you choose to experiment with making some glutathione without testing try turmeric/curcumin (if you suspect gut issues or autoimmunity I'd use curcumin because you don't need black pepper to activate curcuminoids unlike turmeric) or a 2:1 ratio of glutamine and glycine (<800 urine sulfate suggested, but if you feel like you have a ton of cysteine which can cause pressure headaches by the way then go for it,
if glutamine bothers you, wait until later for the aminos) low dose P-5-P and R-5-P with magnesium glycinate can help too.
It's also possible that whenever you take PC the body is breaking it down into TMG thereby stimulating BHMT function and bypassing potential MTR/MTRR defects and now that the methylation block up stream from CBS is gone your body can't clear what's being sent fast enough, if you think that's the case try zinc along with PC. If that doesn't work check COMT and VDR taq status to determine your tolerance for methyl groups, you might be overstimulating with PC if you are a slow burner of dopamine, just a couple ideas to address those headaches, happy hunting!
https://rarediseases.org/rare-diseases/glutathione-synthetase-deficiency/
http://www.heartfixer.com/AMRI-Nutrigenomics.htm (glutamine sensitivity - BHMT activity)