Pyrrhus
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Unfortunately, all of Dr. Montoya's ME/CFS research and clinical studies were abandoned when he left Stanford. He now works in the field of toxoplasmosis.
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Bhupesh Prusty: "we are on a perfect path for identifying potential transferable factors in ME/CFS blood that can cause mito dysfunction..." GoFundMe
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Unfortunately, all of Dr. Montoya's ME/CFS research and clinical studies were abandoned when he left Stanford. He now works in the field of toxoplasmosis.
bthompsonjr1993
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But this video was shot after he left Stanford. So why is he there asking questions of what you said is true?
Pyrrhus
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The video says the talk took place in April 2019.
Montoya left Stanford in May 2019, so it would have been very soon after this talk.
Hope this helps.
bthompsonjr1993
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Ohhh okay thank you. I thought he left in 2018
Murph
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Yes, OMF funds a range of research centres. This is overlooked but it's actually a Foundation not a lab. It has just opened one in Australia!!
That said, the foudnation runs under the eye of the board, which is influenced by Davis, and I do suspect he has his biases, as we all do. e.g. I certainly wouldn't have funded the metabolic trap guy, but I suspect there's something about a grey-haired Palo Alto resident cracking the code through sheer independent brilliance that Ron finds appealling. Overall though, I think OMF is a force for good and even if they put some eggs in some dodgy baskets, they're not putting all their eggs in one basket.
Rufous McKinney
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That was a Major Announcement- I'm super jazzed about more work with Dr.Armstrong.
We gotta get some money....flowing here.
junkcrap50
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Found a data analyst (who I follow for COVID science), with no relation to ME/CFS, discussing Prusty's research and ME/CFS! Great that with COVID, more people are tuning into ME/CFS. He's been digging into the ME/CFS research. He's chatted on twitter with @debored13 and ME/CFS researcher Amy Proal.
Hard to copy and past all his tweets as he comments and retweets in multiple threads. But here's his theory on what the "something in the plasma" is. Click on each tweet and read the whole tweet thread (tweets above and below).
Hard to copy and past all his tweets as he comments and retweets in multiple threads. But here's his theory on what the "something in the plasma" is. Click on each tweet and read the whole tweet thread (tweets above and below).
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Mdivi again. I read about it again and again and how wonderful it is for fragmented mitochondria and possible for us. But it has never been used in a human once and i dont know why. Some animal tests but nothing further. For years now. Annoying. Because it could be big for us.
@MonkeyMan
SS31 would be an s.c. injection everyday till the end of days probably. Mdivi could be taken oral.
Mdivi directly inhibits drp1, SS31 does not.
Mdivi is also way cheaper.
Also there is the possibility of both combined.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884714/
SS31 would be an s.c. injection everyday till the end of days probably. Mdivi could be taken oral.
Mdivi directly inhibits drp1, SS31 does not.
Mdivi is also way cheaper.
Also there is the possibility of both combined.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5884714/
mitoMAN
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As Badpack said - unlike SS-31 ... mitochondrial division inhibitor 1 (Mdivi-1) is a selective inhibitor of dynamin-related protein 1 (Drp1 )
https://www.sciencedirect.com/science/article/pii/S2213231720309113?via=ihub
Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity
https://www.sciencedirect.com/science/article/pii/S2213231720309113?via=ihub
Mdivi-1 attenuates oxidative stress and exerts vascular protection in ischemic/hypoxic injury by a mechanism independent of Drp1 GTPase activity
I worked out I may have a complement factor I partial immune deficiency
https://medlineplus.gov/genetics/condition/complement-factor-i-deficiency/#inheritance
Says it effects c3
https://medlineplus.gov/genetics/condition/complement-factor-i-deficiency/#inheritance
Says it effects c3
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paul80
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"Bhupesh Im testing my C1q auto antibodies next week. I am so excited ha ha! "
Why is she so excited, is there anything you can do about having these antibodies?
Why is she so excited, is there anything you can do about having these antibodies?
Pyrrhus
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Sometimes, IVIG treatment can down-regulate the auto-antibodies so they don't cause problems.
Doesn't always work, though. But it's quite nice when it does.
wigglethemouse
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In one of his presentations Bhupesh Prusty explained he was looking for herpes viruses in tissue from brains (from Cambridge?). I wonder if he is referring to this work???? I don't think he has published on this yet. Interesting............
wigglethemouse
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Found the presentation starting at 12mins - March 2020 CMRC Conference
i believe that is incorrect.