B2 I love you!

Messages
11
Guys this study seems interesting:

Relation of Riboflavin Deficiency to Corticosteroid
Metabolism and Red Cell Hypoplasia in Baboons
HENRY FOY, ATHENA KONDI AND ZULFIKARALI H. M. VERJEE
Wellcome Trust Research Laboratories, P.O. Box 30141, Nairobi, Kenya
ABSTRACT Riboflavin deficiency was produced by feeding baboons a bal
anced artificial diet lacking only riboflavin. In the deprived animals structural
and functional changes occurred in the adrenal cortex. These changes were ac
companied by an erythroid hypoplasia similar to that seen in African children
with marasmus and kwashiorkor during the recovery syndrome, and responded
to parenteral riboflavin or oral prednisone in both children and baboons. The
adrenal cortex in the deprived hypoplastic baboons was hemorrhagic and fibrotic.
The 24-hour urinary 17-hydroxycorticosteroid and 17-oxosteroid in the riboflavindeficient
baboons were low when compared with pair-fed baboons and those on
a natural diet. Terminally the plasma 11-hydroxycorticosteroids were raised, per
haps related to the high transcortin levels. ACTH stimulation in the riboflavindeprived animals gave very low or no response, whereas in the pair-fed and natural diet animals the increase was eightfold in the urinary steroids and be
tween 35 and 50% in the plasma steroids
. The effect that riboflavin deficiency
has on the physiological and morphological state of the adrenal cortex is dis
cussed in relation to marrow activity. Severe skin lesions occurred in all the
riboflavin-deprived baboons which responded rapidly and completely to riboflavin
but not to prednisone. J. Nutr. 102: 571-582, 1972.

source:http://jn.nutrition.org/content/102/4/571.full.pdf

I am no doctor, but it seems that riboflavin deficiency causes a decrease in steroid
hormone production.
 

Little Bluestem

All Good Things Must Come to an End
Messages
4,930
Hi cfs8years,

Welcome to the board. Dont worry about the too much information. It is often necessary when discussing health problems.

See this thread for ways to connect with others who are interested in Christines theories.
forums.phoenixrising.me/showthread.php?17235-new-forum

Have you seen the thread on Anemia of Chronic Disease? If not, you might find it interesting.
forums.phoenixrising.me/showthread.php?17514-Anemia-of-chronic-disease-in-ME-CFS
 

Hanna

Senior Member
Messages
717
Location
Jerusalem, Israel
Hi, Hanna and chilove.

By "plain" B12, I hope she meant hydroxocobalamin, not cyanocobalamin. The latter, taken in large dosage, puts a lot of cyanide into the body, and I have encountered one case in which the person developed cyanide toxicity, which is dangerous.

Best regards,

Rich

Hi Rich,
Thanks for caring. I think she thought of cyanoB12. I am also concerned by its toxicity, so will take hydroxyB12.
 

Hanna

Senior Member
Messages
717
Location
Jerusalem, Israel
Hi Asklipia,

I am quite sure Chrisitine makes a difference between adb12 and mb12, and wouldn't consider adb12 amethyl donor. Though, She didn't give any further explanantion. Sorry that I can't help much...
 

Gavman

Senior Member
Messages
316
Location
Sydney
Did anyone notice any change in their muscle fatigue/recovery/strength while taking manganese?
My dream recall and ability to visualise things is increasing quite well with b6 and zinc. I'm only occasionally taking b2. I don't have energy/mood difficulties any more, its more the failing of strength - i taught/trained martial arts for 2 1/2 hours in a row last week, but i do notice if i utilise adrenaline, strength or speed then my muscles fatigue quickly and are overly sore the next few days.
 

hixxy

Senior Member
Messages
1,229
Location
Australia
For anyone from the UK/Europe who's interested. There's a liquid form of riboflavin 5 phosphate available at: http://www.metabolics.com/Liquid-Vitamins/Riboflavin-5-Phosphate-250ml/flypage_images.tpl.html

Serving Size 1 drop
Amount Per Serving ECRDA
Riboflavin-5-Phosphate (of which Phosphorus, 1.7 mg) 33.3 mg < 1%
Riboflavin-5-Phosphate (of which Riboflavin (B2), 31.6 mg) 3159%
* Percentage Daily Values are based on a 2,000 calorie diet.
Daily Value not established.
Just stumbled upon it during my googles!
 

hixxy

Senior Member
Messages
1,229
Location
Australia
I've taken 100mg of R5P per day before, likewise I was on 7.5mg of manganese in picolinate form. This was last year for about 6 months.

Have people only had success stimulating healing / detox with B2, after removing all other supplements and including manganese with it only?

Is this because the lack of the other supplements leaves more b2 for these healing / detox processes?
 

roxie60

Senior Member
Messages
1,791
Location
Central Illinois, USA
when u say head buzzing do yo mean ear ringing?

Rusty I had detox reations starting withing a couple of hours of my first dose of B2. Sinus draining (extreme), too tired to lift my arms, mild headache, increased fatigue. I definitely did less last week and couldn't walk the kids to the school bus. I slept 9 hours every night.
I took psyllium, pectin, charcoal all of which helped...or some of which. Who knows? Helped anyway!

Then I dropped back to a small dose and added in some manganese. I tried the bigger (12.5) doses again yesterday and had increased all over tiredness but nothing extreme. No headache - so perhaps the manganese helped there as aq suggested?

GL to all trying B2 :))
Anne.

PS ETA I can now take 5000mg sublingual B12 with no head buzzing.
 
Messages
11
I have been taking B2 now for 4 days. 75mg in divided
doses. First day I felt a very warm feeling in my back area
which I think is a copper or iron detox. I had lots of brain
fog and my stools the first 2 days were very smelly. These
are good signs

Unfortunately the last 2 days I have been sleeping a lot! Like
12-13 hours straight. It doesn't feel like I am detoxing at this
moment, but I still have this sleepy feeling. Pretty sure my
liver is being overtaxed. I am going to stop the b2 for one
day and then start at a much lower dosage.

Untill now I haven't read Christine's reasoning for adding
B2. I did read here thoughts on manganese and choline
and its influence on the liver's Endoplasmic Reticulum(spelling?).
How did she find out about b2 deficiency?

Another thing I don't see being addressed is what influence
taking manganese has on other minerals. I read that
manganese has a antagonistic and synergistic effect on
chromium. I know from experience that chromium is antagonistic
to copper.

And what about B2 depleting other vitamins? I think at this moment
it would be better not to continue this protocol as there is too little
information.

I registered on the new hairanalysis forum, but still can't post there.
I get this when I try to login:

''The specified username is currently inactive. If you have problems activating your account, please contact a board administrator.''

The forum administrator contacted me via my hotmail address asking why
I haven't posted. Funny thing is I can't reply as the email address is unknown,
so I can't reply to this message without knowing who to reply to. This is the
first time I have received an email that does not contain the email address of
mailer.

I hope somebody can get in contact with Christine about these and
other questions.
 

justy

Donate Advocate Demonstrate
Messages
5,524
Location
U.K
If this was my nightmare, I would definitely examine the specific content in greater depth. Nightmares are usually signals of distress from the psyche, that refer to the state of the mind or body, using a greatly exaggerated bunch of metaphors in order to get your attention. (touche! it looks like they did that!) Without knowing what these nightmares are exactly about, it's hard to assess what they might be trying to tell you. Since you had the same kind of nightmares when you were at your "most sick," there may be some similarity to what is going on now to what was happening then.

My name is Dreambirdie for a reason you know. :Retro wink::Retro smile::Retro smile:

Hi Dreambirdie - this thread has run away with me and i only just found your post!
The nightmares relate to a very very evil man who is trying to kill me and those around me. In this instance i actually thought in my dream -'oh my god - not the serial killer again!' he dosent kill me but is very very menacing and chases me around on buses etc. In one dream he sliced womens heads opn with some kind of an electric band saw while they were alive - it was so nasty ans distressing. Sometimes there is a nasty sexual nature to his antics. I am very very afraid of him. Do you know the story of bluebeard? i think that tells me something about my psyche in terms of this nightmare. Anyway - i had it a lot when i was severely ill, then as my sleep and health improved it went away. The only times it has come back has been when i have taken the B2 - weird eh?
 

Gavman

Senior Member
Messages
316
Location
Sydney
I got a massive temple headache two days ago. Was trialling supplements two at a time every few hours. Took B2 and it disappeared. I'm gonna start upping my doses of it now. Today i went shopping and felt calm throughout, didn't buy one food that wasn't healthy. good times.
 

Vegas

Senior Member
Messages
577
Location
Virginia
I have been taking B2 now for 4 days. 75mg in divided
doses. First day I felt a very warm feeling in my back area
which I think is a copper or iron detox. I had lots of brain
fog and my stools the first 2 days were very smelly. These
are good signs

Unfortunately the last 2 days I have been sleeping a lot! Like
12-13 hours straight. It doesn't feel like I am detoxing at this
moment, but I still have this sleepy feeling. Pretty sure my
liver is being overtaxed. I am going to stop the b2 for one
day and then start at a much lower dosage.

And what about B2 depleting other vitamins? I think at this moment
it would be better not to continue this protocol as there is too little
information.

.


I don't have your answers, but I wanted to say that B2 has proven to be a huge benefit to me in reducing P.E.M. and increasing energy in only 10 days or so. I had an especially active weekend (a relative concept I know). I was expecting my Monday morning backlash, but it didn't really materialize. The B2 is definitely associated with a lot of intermittent oxidative stress after a dose, followed by improvement. My initial symptoms were consistent with what happens when I take an iron supplement or use liposomal vitamin c: crushing fatigue that is reminiscent of the effects of HM chelation, but without the same level of CNS symptoms. Obviously these two things have an Fe connection and pro-oxidant connection. Certainly there are other possible conclusions, but it seems the B-complex supplementation obviously didn't meet the B2 need. First dose (100 mg) seemed to be associated with very high absorption as there was no bright yellow colored urine. Backed down to much lower dosage as the B2 is wearing me out, but given time to rest, I feel quite good.

Seems I'm getting both the benefits of GSH recycling (GSH reductase) and perhaps the short-term detriments of the oxidoreductase reaction, which I presume is what Christine is referring to as I believe this enzyme can induce mobilization of iron, especially from the liver. What a trip.
 

Vegas

Senior Member
Messages
577
Location
Virginia
& further

Just wanted to add. The heavier "side effects" were associated with nausea...like I get with an iron supplement. I have definitely experienced lots of sweating, a typical "detox" reaction, and my stools are completely rust colored.
 

Gavman

Senior Member
Messages
316
Location
Sydney
'Riboflavin is also needed to help the body change vitamin B6 and folate into forms it can use.'
http://www.umm.edu/altmed/articles/vitamin-b2-000334.htm

Curious on whether the utilised B6 was helping you sleep more, cfs8years.

'Vitamin B6 helps the body make several neurotransmitters, chemicals that carry signals from one nerve cell to another. It is needed for normal brain development and function, and helps the body make the hormones serotonin and norepinephrine, which influence mood, and melatonin, which helps regulate the body clock.'
http://www.umm.edu/altmed/articles/vitamin-b6-000337.htm
 

gu3vara

Senior Member
Messages
339
Just wanted to add. The heavier "side effects" were associated with nausea...like I get with an iron supplement. I have definitely experienced lots of sweating, a typical "detox" reaction, and my stools are completely rust colored.

I've been trying to figure out what the rust color was from, I didn't expect it from b2 and manganese.

I'm sweating a lot too...!
 
Messages
11
I have had very vivid dreams the last couple of days since
starting B2. It might have made b6 more active.

I also had the temple pain. I think Christine mentioned that iron
gets in the amygdala and perhaps the b2 caused the iron to get
released.

Vegas are you saying the B2 initially caused a lot of oxidative stress?
I guess eating antioxidant rich fruit should help.

I didn't have the bright yellow urine the first day either. Was the second
day I think.
 
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