hi Freddd, interesting thread - looks like there might be something to this B12 theory. I'm still going through and reading. I have the methylation panel test ready to go, but just haven't gotten the blood draw yet.
In the meantime, I had standard lab work last week, and while my folate levels apparently have mysteriously risen into the normal zone at 7.6 (5.4 ref.), I'm now B-12 deficient at 118 (223 ref). I don't know why those two things would just reverse like that, kind of weird, although the folate deficiency was a year or so ago. Somehow without supplementing it's become normalized, while the b12 has crashed - maybe some change in diet has done something.
Regarding the B12, what should I do? They want me to take injections, hydroxycobal 1,000mcg. once a month - don't know whether to laugh or cry - but I had bad reactions to b12 injections when i tried them a number of years ago so I won't be doing that regardless.
I have some sublingual methyl b12 here, I think they're 5,000mcg. Occasionally I take about a quarter or 1/8th of one, but it makes me kind of wired, and then my sleep is disrupted even more than normal at night. Should I try the adenosyl, or keep taking the methyl at maybe even smaller doses and hope it levels off after a while?
Hi Mr. Kite,
I guess this is the show tonight. I know of a situation that can cause exactly that. B12 and folate work together in some functions. When active b12 becomes too low in the cells, the cells can suddenly dump their folate into serum, raising the serum level while provoking deficiency symptoms. This is called the "methyl-trap". As RichVank said this can be caused by the methylation block in which then triggers the methyl-trap. It would have the characteristics you have described. Since the serum doesn't use folate, it goes high at the same time as deficient where it is used, in the cells. You can not treat by these test results and expect to have good results.
I have some sublingual methyl b12 here, I think they're 5,000mcg. Occasionally I take about a quarter or 1/8th of one, but it makes me kind of wired,
And here you have the number one most common marker of effectiveness of mb12.
Should I try the adenosyl,
By all means, take it each day a day or two ahead of restarting the mb12. Take the mb12 in the morning as it tends to generate melatonin in the evening normalizing sleep. Right now you have been down so long it feels like up. Your sleep will normalize becoming restorative and restfull and slightly shorter generally, though it may take a little while. As you increase, you can take 1/8 several times a day before increasing to 1/4, building up to several a day before taking half, etc. Keep going because the effects won't stop until more mb12 stops making a difference. At 1/4 table it will continue for months. At two tablets it might last a couple of weeks. At up to 1/2 tablet or so it may never let up as it is very slow to reach equilibrium. One thing you can do is take 2 tablets one day in a single dose and it likely not be too much more intense than 1/2 a tablet. Then drop back to 1/2 a tablet and start building up again. That can take the edge off on a daily basis. The total of length of reaction times intensity of reaction is approximately a constant. The higher the dose the faster you get through it. Energy doesn't come back without coming back. And that change is what you feel. After your body reaches saturation with mb12 the change will no longer be noticable as your "set-point" comes down to normal. Also don't forget all the basics plus Metafolin plus adbv12. Then the "critical cofactors" can come afterward when you know what is still there.